Author

K. M. Hastie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Assay:cryo-EM· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1 Organism:human· 1

Frequent Co-Authors

E. O. Saphire· 4 shared S. Crotty· 2 shared S. L. Schendel· 2 shared S. Landeras-Bueno· 2 shared A. Agarwal· 1 shared A. C. Gayton· 1 shared A. D. Luster· 1 shared A. Frazier· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersImmunology

E. O. Saphire

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Identification of mouse CD4+ T cell epitopes in SARS-CoV-2 BA.1 spike and nucleocapsid for use in peptide:MHCII tetramers

L. Bricio Moreno, J. Barreto de Albuquerque, J. M. Neary, T. Nguyen, K. M. Hastie, S. Landeras-Bueno, C. Hariharan, A. Nathan, M. A. Getz, A. C. Gayton, A. Khatri, G. D. Gaiha, E. O. Saphire, A. D. Luster, J. J. Moon

The paper identifies SARS-CoV-2 BA.1 epitopes recognized by mouse CD4+ T cells and generates corresponding tetramer reagents for studying immune responses.

bioRxiv · Nov 16, 2023 · PreprintImmunology

Structural basis for antibody-mediated neutralization of Lymphocytic choriomeningitis virus

A. Moon-Walker, Z. Zhang, D. S. Zyla, T. K. Buck, H. Li, R. Diaz Avalos, S. L. Schendel, K. M. Hastie, S. Crotty, E. O. Saphire

This study presents the cryoEM structure of LCMV surface glycoprotein and shows that the antibody M28 neutralizes the virus by stabilizing its prefusion state, offering a therapeutic candidate for LCMV infection.

bioRxiv · Jul 17, 2022Microbiology

Structure of the rabies virus glycoprotein trimer bound to a pre-fusion specific neutralizing antibody

H. M. Callaway, D. Zyla, K. M. Hastie, R. D. Avalos, A. Agarwal, H. Bourhy, D. Corti, E. O. Saphire

The paper reports the cryo-EM structure of pre-fusion rabies virus glycoprotein bound to the neutralizing antibody RVA122, revealing its trimeric interface and stabilization mechanism.

bioRxiv · Nov 16, 2021 · PreprintMicrobiology

Molecular assembly of measles and Nipah virus: specific lipid binding drives conformational change and matrix polymerization

M. J. Norris, M. L. Husby, W. B. Kiosses, J. Yin, L. J. Rennick, A. Heiner, S. S. Harkins, R. Pokhrel, S. L. Schendel, K. M. Hastie, S. Landeras-Bueno, Z. Li Salie, B. Lee, P. P. Chapagain, A. Maisner, , E. Ollmann Saphire

This study identifies how measles and Nipah virus M proteins bind specific lipids, inducing conformational changes that drive virion assembly.

bioRxiv · Oct 11, 2021 · PreprintMicrobiology

Immunological memory to SARS-CoV-2 assessed for up to eight months after infection

J. M. Dan, J. Mateus, Y. Kato, K. M. Hastie, E. D. Yu, C. Faliti, A. Grifoni, S. I. Ramirez, S. Haupt, A. Frazier, C. Nakao, V. Rayaprolu, S. A. Rawlings, B. Peters, F. Krammer, , S. Crotty

The paper assesses SARS-CoV-2 immune memory components over eight months post-infection, finding varying kinetics in antibodies, B cells, and T cells.

bioRxiv · Nov 15, 2020 · PreprintImmunology