Author

E. Olmedillas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Assay:cryo-EM· 1 Approach:microscopy & imaging analysis· 1 Assay:protein sequence· 1

Frequent Co-Authors

E. Ollmann Saphire· 3 shared S. Shresta· 2 shared A. Castro· 1 shared A. E. Clark· 1 shared A. F. Carlin· 1 shared A. Thitithanyanont· 1 shared C. J. Mann· 1 shared C. Seephetdee· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersImmunology

E. Ollmann Saphire

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation

E. Olmedillas, R. R. Rajamanickam, R. Diaz, F. A. Sosa Batiz, M. A. Zandonatti, S. S. Harkins, S. Shresta, K. Hastie, E. O. Saphire

This study presents a pre-fusion, open conformation of the SARS-CoV-2 S2 subunit and identifies antibodies that recognize it, providing insights into spike dynamics and potential vaccine targets.

bioRxiv · Dec 14, 2023Microbiology

Structure selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern

G. Almanza, V. Kouznetsova, A. E. Clark, E. Olmedillas, A. Castro, I. F. Tsigelny, Y. Wu, G. F. Gao, E. Ollmann Saphire, A. F. Carlin, M. Zanetti

This study shows that structure-selected RBM immunogens induce polyclonal memory responses that neutralize SARS-CoV-2 variants of concern.

PLOS Pathogens · Jul 21, 2022Peer-reviewedImmunology

Broad neutralization of SARS-CoV-2 variants by circular mRNA producing VFLIP-X spike in mice

C. Seephetdee, K. Bhukhai, N. Buasri, P. Leelukkanaveera, P. Lerdwattanasombat, S. Manopwisedjaroen, N. Phueakphud, S. Kuhaudomlarp, E. Olmedillas, E. Ollmann Saphire, A. Thitithanyanont, S. Hongeng, P. Wongtrakoongate

This study shows that a circular mRNA vaccine encoding VFLIP-X spike protein induces broad neutralizing antibodies against SARS-CoV-2 variants in mice.

bioRxiv · Mar 17, 2022 · PreprintImmunology

Structure-based design of a highly stable, covalently-linked SARS-CoV-2 spike trimer with improved structural properties and immunogenicity

E. Olmedillas, C. J. Mann, W. Peng, Y.-T. Wang, R. Diaz Avalos, D. Bedinger, K. Valentine, N. Shafee, S. L. Schendel, M. Yuan, G. Lang, R. Rouet, D. Christ, W. Jiang, I. A. Wilson, , E. Ollmann Saphire

This paper designs a modified SARS-CoV-2 spike trimer, VFLIP, with enhanced stability, immunogenicity, and structural fidelity to the native spike.

bioRxiv · May 6, 2021 · PreprintMicrobiology