Author

E. Ollmann Saphire

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

E. Olmedillas· 3 shared C. Mann· 2 shared G. Alter· 2 shared S. Fischinger· 2 shared S. L. Schendel· 2 shared A. Castro· 1 shared A. E. Clark· 1 shared A. F. Carlin· 1 shared

Activity by Year

2021-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersImmunology

E. Olmedillas

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Plasmodium infection disrupts the T follicular helper cell response to heterologous immunization

M. Fontana, E. Ollmann Saphire, M. Pepper

This study shows that Plasmodium infection impairs T follicular helper cell responses to heterologous immunization, despite functional dendritic cells.

bioRxiv · Sep 20, 2022Immunology

Structure selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern

G. Almanza, V. Kouznetsova, A. E. Clark, E. Olmedillas, A. Castro, I. F. Tsigelny, Y. Wu, G. F. Gao, E. Ollmann Saphire, A. F. Carlin, M. Zanetti

This study shows that structure-selected RBM immunogens induce polyclonal memory responses that neutralize SARS-CoV-2 variants of concern.

PLOS Pathogens · Jul 21, 2022Peer-reviewedImmunology

Hybrid immunity shifts the Fc-effector quality of SARS-CoV-2 mRNA vaccine-induced immunity

K. A. Bowman, D. Stein, S. Shin, K. G. Ferbas, N. Tobin, C. Mann, S. Fischinger, E. Ollmann Saphire, D. Lauffenberger, A. Rimoin, G. Aldrovandi, G. Alter

This study compares the humoral immune response in individuals with and without prior COVID-19 after mRNA vaccination, finding that hybrid immunity enhances Fc-effector quality rather than quantity.

bioRxiv · Jun 10, 2022Immunology

Broad neutralization of SARS-CoV-2 variants by circular mRNA producing VFLIP-X spike in mice

C. Seephetdee, K. Bhukhai, N. Buasri, P. Leelukkanaveera, P. Lerdwattanasombat, S. Manopwisedjaroen, N. Phueakphud, S. Kuhaudomlarp, E. Olmedillas, E. Ollmann Saphire, A. Thitithanyanont, S. Hongeng, P. Wongtrakoongate

This study shows that a circular mRNA vaccine encoding VFLIP-X spike protein induces broad neutralizing antibodies against SARS-CoV-2 variants in mice.

bioRxiv · Mar 17, 2022 · PreprintImmunology

Molecular assembly of measles and Nipah virus: specific lipid binding drives conformational change and matrix polymerization

M. J. Norris, M. L. Husby, W. B. Kiosses, J. Yin, L. J. Rennick, A. Heiner, S. S. Harkins, R. Pokhrel, S. L. Schendel, K. M. Hastie, S. Landeras-Bueno, Z. Li Salie, B. Lee, P. P. Chapagain, A. Maisner, , E. Ollmann Saphire

This study identifies how measles and Nipah virus M proteins bind specific lipids, inducing conformational changes that drive virion assembly.

bioRxiv · Oct 11, 2021 · PreprintMicrobiology

Subtle immunological differences in mRNA-1273 and BNT162b2 COVID-19 vaccine induced Fc-functional profiles

P. Kaplonek, D. Cizmeci, S. Fischinger, A.-r. Collier, T. Suscovich, C. Linde, T. Broge, C. Mann, F. Amanat, D. Dayal, J. Rhee, M. de St. Aubin, E. J. Nilles, E. R. Musk, A. S. Menon, , G. Alter

This study compares the Fc-functional antibody profiles of mRNA-1273 and BNT162b2 vaccines in a cohort of hospital staff, finding differences in epitope-specific responses and effector functions.

bioRxiv · Aug 31, 2021 · PreprintImmunology

Structure-based design of a highly stable, covalently-linked SARS-CoV-2 spike trimer with improved structural properties and immunogenicity

E. Olmedillas, C. J. Mann, W. Peng, Y.-T. Wang, R. Diaz Avalos, D. Bedinger, K. Valentine, N. Shafee, S. L. Schendel, M. Yuan, G. Lang, R. Rouet, D. Christ, W. Jiang, I. A. Wilson, , E. Ollmann Saphire

This paper designs a modified SARS-CoV-2 spike trimer, VFLIP, with enhanced stability, immunogenicity, and structural fidelity to the native spike.

bioRxiv · May 6, 2021 · PreprintMicrobiology