Author

S. L. Schendel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:cryo-EM· 3 Research Focus:protein structure prediction· 2 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

E. O. Saphire· 3 shared D. Parekh· 2 shared E. Ollmann Saphire· 2 shared K. M. Hastie· 2 shared R. Diaz Avalos· 2 shared A. Baum· 1 shared A. Heiner· 1 shared A. Maisner· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

E. O. Saphire

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Intracellular Ebola Virus nucleocapsid assembly revealed by in situ cryo-electron tomography.

R. Watanabe, D. Zyla, D. Parekh, C. Hong, Y. Jones, S. L. Schendel, W. Wan, G. Castillon, E. O. Saphire

This study uses cryo-electron tomography to reveal the structure of the intracellular Ebola virus nucleocapsid, identifying a new outer layer of NP complexed with VP35 and conserved assembly interfaces.

bioRxiv · Dec 1, 2023Microbiology

Structure of the Inmazeb cocktail and resistance to escape against Ebola virus

V. Rayaprolu, B. Fulton, A. Rafique, E. Arturo, D. Williams, C. Hariharan, H. Callaway, A. Parvate, S. L. Schendel, D. Parekh, S. Hui, K. Shaffer, K. E. Pascal, E. Wloga, S. Giordano, , E. O. Saphire

The paper presents the cryoEM structure of the Inmazeb cocktail in complex with Ebola virus glycoprotein, showing how the combination prevents escape mutations better than monotherapy.

bioRxiv · Oct 11, 2022Biophysics

Structural basis for antibody-mediated neutralization of Lymphocytic choriomeningitis virus

A. Moon-Walker, Z. Zhang, D. S. Zyla, T. K. Buck, H. Li, R. Diaz Avalos, S. L. Schendel, K. M. Hastie, S. Crotty, E. O. Saphire

This study presents the cryoEM structure of LCMV surface glycoprotein and shows that the antibody M28 neutralizes the virus by stabilizing its prefusion state, offering a therapeutic candidate for LCMV infection.

bioRxiv · Jul 17, 2022Microbiology

Molecular assembly of measles and Nipah virus: specific lipid binding drives conformational change and matrix polymerization

M. J. Norris, M. L. Husby, W. B. Kiosses, J. Yin, L. J. Rennick, A. Heiner, S. S. Harkins, R. Pokhrel, S. L. Schendel, K. M. Hastie, S. Landeras-Bueno, Z. Li Salie, B. Lee, P. P. Chapagain, A. Maisner, , E. Ollmann Saphire

This study identifies how measles and Nipah virus M proteins bind specific lipids, inducing conformational changes that drive virion assembly.

bioRxiv · Oct 11, 2021 · PreprintMicrobiology

Structure-based design of a highly stable, covalently-linked SARS-CoV-2 spike trimer with improved structural properties and immunogenicity

E. Olmedillas, C. J. Mann, W. Peng, Y.-T. Wang, R. Diaz Avalos, D. Bedinger, K. Valentine, N. Shafee, S. L. Schendel, M. Yuan, G. Lang, R. Rouet, D. Christ, W. Jiang, I. A. Wilson, , E. Ollmann Saphire

This paper designs a modified SARS-CoV-2 spike trimer, VFLIP, with enhanced stability, immunogenicity, and structural fidelity to the native spike.

bioRxiv · May 6, 2021 · PreprintMicrobiology