Author

R. Duggal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Peier· 2 shared A. W. Partridge· 2 shared B. Henry· 2 shared C. J. Brown· 2 shared C. W. Johannes· 2 shared D. P. Lane· 2 shared K. Biswas· 2 shared L. Ge· 2 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

A. Peier

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2 papers

Recent·Most cited

Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application toMdm2/X dual antagonists

A. Chandramohan, H. Josien, T. Yuen, R. Duggal, D. Spiegelberg, L. Yan, Y. C. A. Juang, L. Ge, P. Aronica, H. Y. K. Kaan, Y. H. Lim, A. Peier, B. Sherborne, J. Hochman, S. Lin, , A. W. Partridge

The paper develops design rules for stapled alpha-helical peptides to improve in vivo activity and reduce off-target effects, demonstrating significant improvements in potency and safety.

bioRxiv · Feb 25, 2023 · PreprintBiochemistry

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling

S. Lim, N. Boyer, N. Boo, C. Huang, G. Venkatachalam, Y.-C. A. Juang, M. Garrigou, K. Kaan, K. M. Peh, A. Sadruddin, P. Gopal, R. Duggal, T. Y. Yuen, S. Ng, S. Kannan, , A. W. Partridge

This paper identifies macrocyclic peptides that inhibit KRAS signaling by binding to its hydrophobic pocket, showing on-target activity and improved proteolytic stability.

bioRxiv · Sep 11, 2021Biochemistry