Author

R. Dutcher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

D. Xu· 2 shared H. Hao· 2 shared J. Liu· 2 shared Y. Luo· 2 shared Y. Xu· 2 shared B. Carrick· 1 shared C. Ong· 1 shared C. Qiu· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

D. Xu

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A higher order PUF complex is central to regulation of C. elegans germline stem cells

C. Qiu, S. L. Crittenden, B. Carrick, L. Dillard, S. Costa dos Santos, V. Dandey, R. Dutcher, E. Viverette, R. Wine, J. Woodworth, Z. Campbell, M. Wickens, M. J. Borgnia, J. Kimble, T. Hall

The paper identifies a ternary PUF complex in C. elegans that regulates germline stem cells by repressing and activating gld-1 mRNA through adjacent FBEs.

bioRxiv · Jun 14, 2024 · PreprintBiochemistry

Heparan sulfate selectively inhibits the collagenase activity of cathepsin K

X. Zhang, Y. Luo, H. Hao, J. Krahn, G. Su, R. Dutcher, Y. Xu, J. Liu, L. Pedersen, D. Xu

This study shows heparan sulfate inhibits cathepsin K collagenase activity while preserving peptidase activity, revealing HS as a potential therapeutic target for bone resorption diseases.

Matrix Biology · May 1, 2024Peer-reviewedBiochemistry

Heparan sulfate promotes TRAIL-induced tumor cell apoptosis

Y. Luo, H. Hao, Z. Wang, C. Ong, R. Dutcher, Y. Xu, J. Liu, L. C. Pedersen, D. Xu

This study identifies heparan sulfate as a key regulator of TRAIL-induced apoptosis, showing that HS enhances TRAIL's apoptotic activity by promoting oligomerization and DR5 internalization.

bioRxiv · Jul 26, 2023Cell Biology