H. Hao

Targeting protein tyrosine phosphatase non-receptor type 2 with a novel inhibitor for AML therapy

This study identifies PTPN2 as a therapeutic target in AML, discovers a selective inhibitor K73, and demonstrates its efficacy in reducing AML burden in vitro and in vivo.

SLC13A2-transported citrate is a metabolic signal for PKM2 acetylation and degradation to suppress tumor growth

This paper identifies SLC13A2-transported citrate as a metabolic signal that promotes PKM2 acetylation and degradation, thereby suppressing tumor growth in hepatocellular carcinoma.

Heparan sulfate selectively inhibits the collagenase activity of cathepsin K

This study shows heparan sulfate inhibits cathepsin K collagenase activity while preserving peptidase activity, revealing HS as a potential therapeutic target for bone resorption diseases.

PARP14 is an interferon (IFN)-induced host factor that promotes IFN production and affects the replication of multiple viruses

This paper shows PARP14 promotes IFN production and has both antiviral and proviral functions against multiple viruses.

Neurophysiological Features of STN LFP underlying Sleep Fragmentation in Parkinson's Disease

This study identifies STN LFP features, including beta and gamma oscillations and the low-high power ratio, that correlate with sleep fragmentation in Parkinson's disease patients.

Heparan sulfate promotes TRAIL-induced tumor cell apoptosis

This study identifies heparan sulfate as a key regulator of TRAIL-induced apoptosis, showing that HS enhances TRAIL's apoptotic activity by promoting oligomerization and DR5 internalization.

A Gpr35 tuned gut-brain metabolic axis regulates depressive-like behavior

This study identifies Gpr35 as a regulator of a gut-brain metabolic axis that influences depressive-like behavior in mice, highlighting microbial metabolites as potential therapeutic targets.

Ultra-sensitive platelet proteome maps the O-glycosylation landscape and charts the response to thrombin dosage

This paper presents a high-sensitivity proteome analysis of human platelets, identifying O-glycosylation sites and showing that POFUT1 regulates MMRN1 secretion.

Bile Acid Restrained T Cell Activation Explains Cholestasis Aggravated Hepatitis B Virus Infection

This study shows that bile acids impair CD4+ T cell activation in cholestasis, worsening HBV infection outcomes by disrupting calcium signaling and metabolic reprogramming.

Metagenomic and Metabolomic Analyses Reveal Synergistic Effects of Fecal Microbiota Transplantation and Anti-PD-1 Therapy on Treating Colorectal Cancer

This study shows that combining fecal microbiota transplantation with anti-PD-1 therapy improves survival and tumor control in mice, with specific gut bacteria and metabolites contributing to the enhanced efficacy.

The evolution of fluoroquinolone resistance in Salmonella under exposure to sub-inhibitory concentration of enrofloxacin

This study examines how Salmonella develops resistance to enrofloxacin under varying sub-inhibitory concentrations, identifying gene expression changes and mutations involved in resistance.

Exploration of clinical breakpoint of Danofloxacin for Glaesserella parasuis in plasma and in PELF

This study establishes three clinical breakpoint values for danofloxacin against Glaesserella parasuis using epidemiological, pharmacodynamic, and clinical data.

Chemoproteomics Maps Glycolytic Targetome in Cancer Cells

This study maps the glycolytic targetome in cancer cells using TRAP, revealing 913 targets and 2,487 interactions for 10 glycolytic metabolites and their functional roles in cancer biology.

The Nesprin-1/-2 ortholog ANC-1 regulates organelle positioning in C. elegans without its KASH or actin-binding domains

This study shows ANC-1 in C. elegans regulates organelle positioning without requiring its KASH or actin-binding domains, suggesting a novel mechanism involving its spectrin-like region.

Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition

This paper identifies Apaf-1 pyroptosome as a machinery that senses mitochondrial permeability transition (MPT) and triggers pyroptosis via caspase-4/11 and GSDME.

DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA as Diagnostic Biomarkers for Human Cancers

The paper identifies 5hmC signatures in cfDNA as accurate biomarkers for detecting colorectal and gastric cancers, outperforming conventional markers and matching tissue biopsy results.