Author

R. E. Hughes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:imaging· 2 Approach:deep learning· 1

Frequent Co-Authors

A. F. Munro· 2 shared A. Makda· 2 shared J. R. O'Neill· 2 shared M. Peckham· 2 shared N. O. Carragher· 2 shared T. Hupp· 2 shared A. Curd· 1 shared A. Merits· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

A. F. Munro

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

High-content profiling reveals a unified model of copper ionophore dependent cell death in oesophageal adenocarcinoma

R. E. Hughes, R. J. Elliott, X. Li, A. F. Munro, A. Makda, R. N. Carter, N. M. Morton, K. Fujihara, N. J. Clemons, R. Fitzgerald, J. R. O'Neill, T. Hupp, N. O. Carragher

This study identifies a unified mechanism of copper ionophore-induced cell death in oesophageal adenocarcinoma using high-content profiling and omic analyses.

bioRxiv · Oct 5, 2021 · PreprintCancer Biology

RNASeq analysis of a Pax3-expressing myoblast clone in-vitro and effect of culture surface stiffness on differentiation.

L. Richardson, D. Wang, R. E. Hughes, C. A. Johnson, M. Peckham

The paper analyzes RNASeq data from a Pax3-expressing myoblast clone to investigate how culture surface stiffness affects differentiation, finding enhanced myogenic gene expression on softer surfaces.

bioRxiv · Sep 5, 2021Cell Biology

High Content Phenotypic Profiling in Oesophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug Discovery

R. E. Hughes, R. J. R. Elliott, A. F. Munro, A. Makda, J. R. O'Neill, T. Hupp, N. O. Carragher

This study uses high-content phenotypic profiling to identify drug classes and novel compounds with selective activity against oesophageal adenocarcinoma cell lines.

bioRxiv · Jan 20, 2020Cancer Biology

Persistent Chikungunya Virus Replication in Human Cells is Associated with Presence of Stable Cytoplasmic Granules Containing Non-structural Protein 3

R. Remenyi, Y. Gao, R. E. Hughes, A. Curd, C. Zothner, M. Peckham, A. Merits, M. Harris

This paper identifies stable cytoplasmic granules containing nsP3 in persistently infected CHIKV cells, showing their long-term persistence and implications for chronic disease.

bioRxiv · Feb 14, 2018Microbiology