Author

R. E. Lawrence

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

A. Frost· 1 shared A. J. Samelson· 1 shared C. Parra Bravo· 1 shared D. Eisenberg· 1 shared D. Goodness· 1 shared D. L. Swaney· 1 shared D. R. Southworth· 1 shared E. C. Carroll· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCell Biology

A. Frost

Author profile →

3 papers

Recent·Most cited

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

A. J. Samelson, N. Ariqat, J. McKetney, G. Rohanitazangi, C. Parra Bravo, R. Bose, K. J. Travaglini, V. L. Lam, D. Goodness, G. Dixon, E. Marzette, J. Jin, R. Tian, E. Tse, R. Abskharon, , M. Kampmann

The paper uses CRISPR screens in iPSC-derived neurons to identify factors controlling tau aggregation, finding new pathways and potential therapeutic targets for tauopathies.

bioRxiv · Jun 16, 2023Cell Biology

eIF2B Conformation and Assembly State Regulate the Integrated Stress Response

M. Schoof, M. Boone, L. Wang, R. E. Lawrence, A. Frost, P. Walter

This study shows that eIF2B assembly and conformation regulate the ISR, with ISRIB affecting eIF2B through decamer stabilization and allosteric modulation.

bioRxiv · Dec 28, 2020Cell Biology

Structural mechanism for amino acid-dependent Rag GTPase switching by SLC38A9

S. Fromm, R. E. Lawrence, J. H. Hurley

This paper reveals how SLC38A9 destabilizes the lysosomal FLC complex to promote Rag dimer activation by disrupting the GAP activity toward RagC.

bioRxiv · Jul 28, 2020Biochemistry