Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment
N. Li, Q. Zhu, Y. Tian, K. J. Ahn, X. Wang, Z. Cramer, I. W. Folkert, P. Yu, J. Jou, S. Adams-Tzivelekidis, P. Sehgal, N. N. Mahmoud, C. B. Aarons, R. E. Roses, A. Thomas-Tikhonenko, , C. J. Lengner
This study maps and models human colorectal carcinoma interactions with the tumor microenvironment using single-cell transcriptomics and tumoroid cultures, showing how tumoroids suppress inflammation and reprogram macrophages.
bioRxiv · Sep 13, 2022Cancer Biology