Author

P. Sehgal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Thomas-Tikhonenko· 3 shared B. Z. Stanger· 2 shared C. J. Lengner· 2 shared K. E. Hayer· 2 shared X. Wang· 2 shared A. Castro· 1 shared A. Ferrando· 1 shared A. K. Rustgi· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCancer Biology

A. Thomas-Tikhonenko

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Author profile →

4 papers

Recent·Most cited

An Alternatively Spliced Gain-of-Function NT5C2 Isoform Contributes to Chemoresistance in Acute Lymphoblastic Leukemia

M. T. Diz, C. Reglero, C. D. Falkenstein, A. Castro, K. E. Hayer, C. Radens, M. Quesnel-Vallieres, Z. Ang, P. Sehgal, M. M. Li, Y. Barash, S. K. Tasian, A. Ferrando, A. Thomas-Tikhonenko

The paper identifies an alternatively spliced NT5C2 isoform contributing to chemoresistance in B-ALL by enhancing nucleosidase activity and 6-MP resistance.

bioRxiv · Sep 14, 2023Cancer Biology

Mitochondrial calcium signaling mediated transcriptional regulation of keratin filaments is a critical determinant of melanogenesis

J. Tanwar, K. Ahuja, A. Sharma, P. Sehgal, G. Ranjan, F. Sultan, A. Priya, M. Venkatesan, V. K. Yenamandra, A. K. Singh, M. Madesh, S. Sivasubbu, R. K. Motiani

This study identifies mitochondrial Ca2+ signaling and keratin filaments as critical regulators of melanogenesis, revealing a feedback loop involving MCU, NFAT2, and keratin 5.

bioRxiv · May 26, 2023 · PreprintCell Biology

Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment

N. Li, Q. Zhu, Y. Tian, K. J. Ahn, X. Wang, Z. Cramer, I. W. Folkert, P. Yu, J. Jou, S. Adams-Tzivelekidis, P. Sehgal, N. N. Mahmoud, C. B. Aarons, R. E. Roses, A. Thomas-Tikhonenko, , C. J. Lengner

This study maps and models human colorectal carcinoma interactions with the tumor microenvironment using single-cell transcriptomics and tumoroid cultures, showing how tumoroids suppress inflammation and reprogram macrophages.

bioRxiv · Sep 13, 2022Cancer Biology

MYC hyperactivates WNT signaling in APC/CTNNB1-mutated colorectal cancer cells through miR-92a-dependent repression of DKK3

P. Sehgal, C. Lanauze, X. Wang, K. E. Hayer, M. Torres-Diz, Y. Sela, B. Z. Stanger, C. J. Lengner, A. Thomas-Tikhonenko

This study shows MYC enhances WNT signaling in colorectal cancer cells by repressing DKK3 via miR-92a, creating an oncogenic feedback loop.

bioRxiv · Jul 26, 2021Cancer Biology