Author

R. Feltham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Organism:virus· 1

Frequent Co-Authors

G. Ebert· 2 shared A. E. Au· 1 shared A. I. Webb· 1 shared A. J. Kueh· 1 shared A. Riboldi-Tunnicliffe· 1 shared A. Vince· 1 shared B. C. Lechtenberg· 1 shared B. G. C. Lu· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

G. Ebert

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

The inflammasome-activated cytokine IL-1 is targeted for ubiquitylation and proteasomal degradation to limit its inflammatory potential

S. Vijayaraj, R. Feltham, M. Rashidi, D. Frank, Z. Liu, D. Simpson, G. Ebert, A. Vince, M. J. Herold, A. J. Kueh, J. Pearson, L. Dagley, J. M. Murphy, A. I. Webb, K. E. Lawlor, J. E. Vince

This study shows that IL-1β is ubiquitylated and degraded to limit its inflammatory activity, with specific ubiquitin modifications and electrostatic interactions playing key roles.

bioRxiv · Mar 15, 2021 · PreprintImmunology

Mechanism and inhibition of SARS-CoV-2 PLpro

T. Klemm, G. Ebert, D. J. Calleja, C. C. Allison, L. W. Richardson, J. P. Bernardini, B. G. C. Lu, N. W. Kuchel, C. Grohmann, Y. Shibata, Z. Y. Gan, J. P. Cooney, M. Doerflinger, A. E. Au, T. R. Blackmore, , D. Komander

This study investigates SARS-CoV-2 PLpro's mechanism and identifies non-covalent inhibitors with antiviral activity.

bioRxiv · Jun 18, 2020Biochemistry