Author

A. I. Webb

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 3 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 7 Research Focus:cell signaling & trafficking· 5 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

L. F. Dagley· 4 shared J. J. Sandow· 3 shared G. Infusini· 2 shared J. M. Murphy· 2 shared J. Silke· 2 shared L. Dagley· 2 shared A. Bankovacki· 1 shared A. C. Ching· 1 shared

Activity by Year

2018-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersImmunology

L. F. Dagley

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Physiological Substrates and Ontogeny-Specific Expression of the Ubiquitin Ligases MARCH1 and MARCH8

P. Schriek, H. Liu, A. C. Ching, P. Huang, N. Gupta, K. R. Wilson, M. Tsai, Y. Yan, C. F. Macri, L. F. Dagley, G. Infusini, A. I. Webb, H. McWilliam, S. Ishido, J. D. Mintern, J. A. Villadangos

This study identifies MARCH1 and MARCH8 as specialized regulators of CD4+ T cell immunity in distinct cellular compartments by analyzing their substrates and expression in mice.

bioRxiv · Apr 15, 2021Immunology

Simplified high-throughput methods for deep proteome analysis on the timsTOF Pro

J. J. Sandow, G. Infusini, L. Dagley, R. Larsen, A. I. Webb

The paper describes simplified high-throughput methods for deep proteome analysis using the timsTOF Pro instrument, achieving high protein identifications with short separation gradients.

bioRxiv · Apr 7, 2021 · PreprintBiochemistry

The inflammasome-activated cytokine IL-1 is targeted for ubiquitylation and proteasomal degradation to limit its inflammatory potential

S. Vijayaraj, R. Feltham, M. Rashidi, D. Frank, Z. Liu, D. Simpson, G. Ebert, A. Vince, M. J. Herold, A. J. Kueh, J. Pearson, L. Dagley, J. M. Murphy, A. I. Webb, K. E. Lawlor, J. E. Vince

This study shows that IL-1β is ubiquitylated and degraded to limit its inflammatory activity, with specific ubiquitin modifications and electrostatic interactions playing key roles.

bioRxiv · Mar 15, 2021 · PreprintImmunology

Tankyrase-mediated ADP-ribosylation is a novel regulator of TNF-induced death

L. Liu, J. J. Sandow, D. M. Leslie Pedrioli, N. Silke, Z. Hu, E. Morrish, D. Chau, T. Kratina, A. J. M. Kueh, M. O. Hottiger, A. I. Webb, N. Lalaoui, J. Silke

This study identifies tankyrase-mediated ADP-ribosylation as a regulator of TNF-induced cell death by promoting complex 2 assembly and interacting with RNF146.

bioRxiv · Feb 9, 2021Cell Biology

A regulatory interface on RIPK2 is required for XIAP binding and NOD signaling activity

V. J. Heim, L. F. Dagley, C. Stafford, F. M. Hansen, E. Clayer, A. Bankovacki, A. I. Webb, I. S. Lucet, J. Silke, U. Nachbur

The paper identifies a regulatory interface on RIPK2 essential for XIAP binding and NOD signaling by analyzing post-translational modifications in RIPK2 knock-in mice.

bioRxiv · Mar 12, 2020Cell Biology

Phosphorylation by Aurora B kinase regulates caspase-2 activity and function

S. Kumar, Y. Lim, D. De Bellis, J. J. Sandow, L. Capalbo, P. P. D'Avino, J. M. Murphy, A. I. Webb, L. Dorstyn

This study identifies Aurora B kinase-mediated phosphorylation of caspase-2 at S384, which inhibits its catalytic activity and apoptosis function during mitotic catastrophe.

bioRxiv · Mar 5, 2020Cell Biology

Therapeutic blockade of Activin-A improves NK cell function and anti-tumor immunity

J. Rautela, L. F. Dagley, I. S. Schuster, S. Hediyeh-Zadeh, R. Delconte, J. Cursons, R. Hennessy, D. S. Hutchinson, C. Harrison, C. C. Oliveira, E. Vivier, A. I. Webb, M. Degli-Esposti, M. Davis, N. D. Huntington, F. Souza-Fonseca-Guimaraes

This study shows Activin-A inhibits NK cell function, promotes transdifferentiation into ILC1-like cells, and suppresses anti-tumor immunity, with therapeutic blockade improving outcomes.

bioRxiv · Oct 29, 2018 · PreprintImmunology

Protein Kinase A Negatively Regulates Ca2+ signalling in Toxoplasma gondii

A. D. Uboldi, M.-L. Wilde, E. A. McRae, R. J. Stewart, L. F. Dagley, L. Yang, N. J. Katris, S. V. Hapuarachchi, M. J. Coffey, A. M. Lehane, C. Y. Botte, R. F. Waller, A. I. Webb, C. J. Tonkin

This study shows that Protein Kinase A (PKAc1) suppresses Ca2+ signalling in Toxoplasma gondii after host cell invasion, affecting motility and infectivity.

bioRxiv · Feb 14, 2018Microbiology