R. Franzkoch

Structure and regulation of GSDMD pores at the plasma membrane of pyroptotic cells

The paper visualizes GSDMD nanostructures at the plasma membrane of pyroptotic cells and identifies PI(3,4,5)P3 as a regulator of pore formation.

Resolving exit strategies of mycobacteria by combining high-pressure freezing with 3D-correlative light and electron microscopy

This paper develops a method to study mycobacteria exit strategies using 3D-correlative light and electron microscopy with improved cell adhesion.

ER-dependent membrane repair of mycobacteria-induced vacuole damage

This study identifies OSBP8 as an ER-dependent lipid transfer protein involved in membrane repair of mycobacteria-induced vacuole damage, which is critical for host defense against M. tuberculosis.

Early endosomes act as local exocytosis hubs to repair endothelial membrane damage

The paper shows early endosomes release membrane material via Ca2+-induced exocytosis to repair endothelial cell membrane damage.

From vacuole to cytosol - Disruptive invasion triggers cytosolic release of Salmonella Paratyphi A and subsequent cytosolic motility favors evasion of xenophagy

This study shows that Salmonella Paratyphi A escapes into the host cell cytosol through vacuole damage and uses flagella-mediated motility to evade xenophagy, aiding its survival and spread.

Single molecule analyses of Salmonella translocated effector proteins reveal targeting to and dynamics in host cell endomembranes

The paper uses single molecule analysis to study how Salmonella effector proteins reach and interact with host cell endomembranes, revealing dynamics and mechanisms of membrane remodeling.

Single cell analyses reveal distinct adaptation of typhoidal and non-typhoidal Salmonella enterica serovars to intracellular lifestyle

This study compares the intracellular behavior of typhoidal and non-typhoidal Salmonella using single-cell analyses, revealing differences in SPI2-T3SS activity and protein biosynthesis.