M. Gutierrez

ER-dependent membrane repair of mycobacteria-induced vacuole damage

This study identifies OSBP8 as an ER-dependent lipid transfer protein involved in membrane repair of mycobacteria-induced vacuole damage, which is critical for host defense against M. tuberculosis.

First reported detection of the mobile colistin resistance genes, mcr-8 and mcr-9, in the Irish environment

This study reports the first detection of mcr-8 and mcr-9 genes in Irish environmental samples, highlighting potential environmental reservoirs of colistin resistance.

Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY

This study identifies a proton exchange-based isomerization and lactonization mechanism in the plant enzyme COSY, revealing its unique catalytic activity and evolutionary adaptation.

Electroencephalographic Signatures of Canine Cognitive Dysfunction

This study identifies EEG biomarkers for canine cognitive dysfunction (CCD) and its early stages, showing differences in coherence and complexity between healthy, at-risk, and CCD-affected dogs.

Sorting droplets into many outlets

This paper introduces a droplet sorting system with new electrode and fluidic designs, enabling high-purity cell sorting and industrial-scale manufacturing.

Correlative Light Electron Ion Microscopy reveal in vivo localisation of bedaquiline in Mycobacterium tuberculosis infected lungs

The paper uses CLEIMiT to show bedaquiline accumulates in specific cell types in M. tuberculosis infected lungs.

Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation

This study compares macrophage responses to human- and animal-adapted tuberculosis pathogens, identifying factors that drive multinucleated cell formation in bovine macrophages infected with M. bovis.