Author

R. Gerhard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

E. Latz· 2 shared M. S. J. Mangan· 2 shared A. Akbal· 1 shared A. Heinz· 1 shared A. Schroeder· 1 shared D. Jahn· 1 shared D. Wachten· 1 shared F. Duthie· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

E. Latz

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2 papers

Recent·Most cited

Cytosolic sodium accumulation is a common danger signal triggering endocytic dysfunction and NLRP3 inflammasome activation

M. S. J. Mangan, A. Akbal, S. Rivara, A. Schroeder, G. L. Horvath, P. Walch, J. Hegermann, R. Kaiser, F. Duthie, J. Selkrig, J. Jantsch, R. Gerhard, D. Wachten, E. Latz

The paper shows that cytosolic sodium accumulation triggers NLRP3 inflammasome activation in response to various danger signals in human macrophages.

bioRxiv · Mar 26, 2024 · PreprintImmunology

Clostridium difficile Toxin B activates the NLRP3 inflammasome in human macrophages, demonstrating a novel regulatory mechanism for the Pyrin inflammasome

M. S. J. Mangan, F. Gorki, K. Krause, A. Heinz, T. Ebert, D. Jahn, K. Hiller, V. Hornung, M. Mauer, F. I. Schmidt, R. Gerhard, E. Latz

The paper shows that C. difficile toxin B activates the NLRP3 inflammasome in human macrophages, not the Pyrin inflammasome, and that Pyrin activation can be restored with prolonged priming.

bioRxiv · Jul 7, 2021 · PreprintImmunology