Author

R. Goodwin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:human· 1 Assay:metagenomics· 1 Organism:mouse· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

A. Dannhorn· 1 shared A. G. Schuller· 1 shared B. P. Kaistha· 1 shared D. I. Jodrell· 1 shared D. M. Wall· 1 shared F. M. Richards· 1 shared H. Buckley· 1 shared H. Hulme· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

A. Dannhorn

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2 papers

Recent·Most cited

Microbiome-derived metabolite effects on intestinal barrier integrity and immune cell response to infection

L. Adams, X. Li, R. Burchmore, R. Goodwin, D. M. Wall

This study investigates how gut microbiome-derived metabolites affect intestinal barrier integrity and immune cell responses to infection at the cellular level.

bioRxiv · Feb 6, 2024Microbiology

Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

V. Graziano, A. Dannhorn, H. Hulme, K. Williamson, H. Buckley, S. A. Karim, S. Y. Lee, B. P. Kaistha, S. Islam, J. E. D. Thaventhiran, F. M. Richards, R. Goodwin, R. Brais, J. P. Morton, S. J. Dovedi, , D. I. Jodrell

This study shows that extracellular adenosine promotes an immunosuppressive microenvironment in PDAC by enhancing myeloid cell infiltration and resistance to immunotherapy, and that blocking adenosine pathway components improves therapeutic outcomes.

bioRxiv · May 24, 2022Cancer Biology