Author

D. I. Jodrell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

T. Y. F. Halim· 3 shared J. E. D. Thaventhiran· 2 shared K. Williamson· 2 shared S. Raghunathan· 2 shared A. Dannhorn· 1 shared A. G. Schuller· 1 shared A. Liston· 1 shared A. N. J. McKenzie· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

T. Y. F. Halim

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Tissue-resident regulatory T cells exert dualistic anti-tumour and pro-repair function in the exocrine pancreas

J. Stockis, T. Yip, S. Raghunathan, C. Garcia, S. Lee, C. Simpson, S. Silvain, M. J. Schuijs, J. Araos, S. Png, G. Raddi, O. Bricard, T. Y. So, S. Mack, P. Papadopoulos, , T. Y. F. Halim

This study identifies a rare pancreatic tissue-resident regulatory T cell population that exhibits both anti-tumour and pro-repair functions in the exocrine pancreas.

bioRxiv · Feb 15, 2024 · PreprintImmunology

Fate-mapping lymphocyte clones and their progenies from induced antigen-signals identifies temporospatial behaviours of T cells mediating tolerance

M. Takahashi, T. So, K. Williamson, Z. Hosseini, K. Kania, M. Ruhle, T. Mann, M. J. Schujis, P. Coupland, D. Naisbitt, T. Y. F. Halim, P. A. Lyons, P. Lio, K. Okkenhaug, D. J. Adams, , J. E. D. Thaventhiran

This study introduces a novel fate-mapping mouse to track lymphocyte clones and their progenies in response to antigen signals, revealing distinct T cell behaviors in tumor immunity.

bioRxiv · Mar 16, 2023Immunology

Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

V. Graziano, A. Dannhorn, H. Hulme, K. Williamson, H. Buckley, S. A. Karim, S. Y. Lee, B. P. Kaistha, S. Islam, J. E. D. Thaventhiran, F. M. Richards, R. Goodwin, R. Brais, J. P. Morton, S. J. Dovedi, , D. I. Jodrell

This study shows that extracellular adenosine promotes an immunosuppressive microenvironment in PDAC by enhancing myeloid cell infiltration and resistance to immunotherapy, and that blocking adenosine pathway components improves therapeutic outcomes.

bioRxiv · May 24, 2022Cancer Biology

Early neutrophilia marked by aerobic glycolysis sustains host metabolism and delays cancer cachexia

M. Petruzzelli, M. Ferrer, M. Schuijs, Z. Hall, D. Perera, S. Raghunathan, M. Vacca, E. Gaude, M. J. Lukey, D. I. Jodrell, C. Frezza, E. F. Wagner, T. Janowitz, T. Y. F. Halim, A. R. Venkitaraman

The paper shows that early neutrophilia driven by aerobic glycolysis supports host metabolism and delays cancer cachexia in murine models.

bioRxiv · Aug 11, 2021Cancer Biology