Author

R. H. Clare

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

J. Kool· 2 shared N. R. Casewell· 2 shared A. H. Laustsen· 1 shared A. Westhorpe· 1 shared C. Ulens· 1 shared C. Xie· 1 shared E. Crittenden· 1 shared J. Alsolaiss· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPharmacology & Toxicology

J. Kool

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2 papers

Recent·Most cited

An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules

R. N. Patel, R. H. Clare, L. Ledsgaard, M. Nys, J. Kool, A. H. Laustsen, C. Ulens, N. R. Casewell

This paper develops an in vitro assay to screen for venom neurotoxin activity on muscle-type nAChR and identify toxin-inhibitory molecules, showing robust assay performance across 96-well plates.

bioRxiv · Apr 28, 2023 · PreprintPharmacology & Toxicology

In vitro and in vivo venom-inhibition assays identify metalloproteinase-inhibiting drugs as potential treatments for snakebite envenoming by Dispholidus typus

S. K. Menzies, R. H. Clare, C. Xie, A. Westhorpe, S. R. Hall, R. J. Edge, J. Alsolaiss, E. Crittenden, R. A. Harrison, J. Kool, N. R. Casewell

This study evaluates four SVMP inhibitors for treating D. typus snakebite envenoming, finding DMPS and marimastat effective in preclinical models.

bioRxiv · Jan 7, 2022 · PreprintPharmacology & Toxicology