E. Crittenden

Dermonecrosis caused by spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib

This study identifies toxin synergism in spitting cobra venom causing dermonecrosis and shows that varespladib prevents tissue damage in mouse models.

Machine-learning guided Venom Induced Dermonecrosis Analysis tooL: VIDAL

VIDAL is a machine-learning tool that automatically analyzes dermonecrosis in mouse models to assess antivenom efficacy, offering an accurate and reproducible alternative to manual methods.

Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms

The paper shows repurposed drugs and their combinations reduce cytotoxicity of snake venoms in cell and mouse models, offering potential new treatments for snakebite envenoming.

Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: results of preclinical efficacy testing

This study evaluates two antivenoms as alternatives to SAIMR Polyvalent in Eswatini, finding they are equally or more effective against the most common snake venom but less effective against others.

Exploring the utility of recombinantly expressed snake venom serine protease toxins as immunogens for generating experimental snakebite antivenoms

This study evaluates recombinant snake venom serine protease toxins as immunogens to generate antivenoms that target specific venom-induced pathologies.

In vitro and in vivo venom-inhibition assays identify metalloproteinase-inhibiting drugs as potential treatments for snakebite envenoming by Dispholidus typus

This study evaluates four SVMP inhibitors for treating D. typus snakebite envenoming, finding DMPS and marimastat effective in preclinical models.

A combination of two small molecule toxin inhibitors provides pancontinental preclinical efficacy against viper snakebite

This study shows that a combination of two small molecule inhibitors effectively neutralizes viper venom in vitro and prevents lethality in vivo across multiple regions.

Preclinical validation of a repurposed metal chelator as a community-based therapeutic for hemotoxic snakebite

This paper shows that the metal chelator DMPS can effectively treat hemotoxic snakebite in mice, both when given orally and in combination with antivenom.