R. A. Harrison

Dermonecrosis caused by spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib

This study identifies toxin synergism in spitting cobra venom causing dermonecrosis and shows that varespladib prevents tissue damage in mouse models.

Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: results of preclinical efficacy testing

This study evaluates two antivenoms as alternatives to SAIMR Polyvalent in Eswatini, finding they are equally or more effective against the most common snake venom but less effective against others.

Exploring the utility of recombinantly expressed snake venom serine protease toxins as immunogens for generating experimental snakebite antivenoms

This study evaluates recombinant snake venom serine protease toxins as immunogens to generate antivenoms that target specific venom-induced pathologies.

In vitro and in vivo venom-inhibition assays identify metalloproteinase-inhibiting drugs as potential treatments for snakebite envenoming by Dispholidus typus

This study evaluates four SVMP inhibitors for treating D. typus snakebite envenoming, finding DMPS and marimastat effective in preclinical models.

Convergent Evolution of Pain-Inducing Defensive Venom Components in Spitting Cobras

This study shows that three spitting cobra lineages independently evolved venom with increased pain-enhancing toxins, likely in response to hominin emergence.

A combination of two small molecule toxin inhibitors provides pancontinental preclinical efficacy against viper snakebite

This study shows that a combination of two small molecule inhibitors effectively neutralizes viper venom in vitro and prevents lethality in vivo across multiple regions.

Evaluation of the geographical utility of Eastern Russells viper (Daboia siamensis) antivenom from Thailand and an assessment of its protective effects against venom-induced nephrotoxicity

This study evaluates the effectiveness of Thai-made D. siamensis antivenom against venoms from Myanmar, Taiwan, and Thailand, showing it can neutralize coagulopathy and nephrotoxicity but requires high doses early for efficacy.

Preclinical validation of a repurposed metal chelator as a community-based therapeutic for hemotoxic snakebite

This paper shows that the metal chelator DMPS can effectively treat hemotoxic snakebite in mice, both when given orally and in combination with antivenom.

The diversity, evolution and ecology of Salmonella in venomous snakes

This study investigates Salmonella diversity in venomous snakes, finding 91% prevalence and identifying metabolic differences between subspecies, suggesting a potential role in human Salmonellosis in Africa.