R. H. Gomer

Gallein and isoniazid act synergistically to attenuate Mycobacterium tuberculosis growth in human macrophages

This study shows that gallein and isoniazid work together to reduce Mycobacterium tuberculosis growth in human macrophages by inhibiting polyphosphate accumulation.

Polyphosphate uses mTOR, pyrophosphate, and Rho GTPase components to potentiate bacterial survival in Dictyostelium

This paper identifies key components of the polyP signaling pathway in D. discoideum that inhibit bacterial killing, suggesting potential therapeutic targets for enhancing macrophage pathogen clearance.

Starvation induces extracellular accumulation of polyphosphate in Dictyostelium discoideum to inhibit macropinocytosis, phagocytosis, and exocytosis

This study shows that starvation in Dictyostelium discoideum increases extracellular polyphosphate, which inhibits macropinocytosis, phagocytosis, and exocytosis by reducing membrane fluidity.

Inhibiting a mRNA motif binding protein that mediates TGF-β1 upregulation of translation attenuates pulmonary fibrosis in mice

The paper identifies an mRNA motif regulated by TGF-β1 that enhances translation of NEU3, and shows that inhibiting the binding protein DDX3 reduces pulmonary fibrosis in mice.

Changes in lung sialidases in male and female mice after bleomycin aspiration

This study examines changes in lung sialidase expression in male and female mice after bleomycin aspiration, finding differential expression patterns and fibrosis association with NEU3.

The extracellular sialidase NEU3 induces neutrophil priming

This study shows that NEU3 sialidase primes human neutrophils by altering morphology, cortical marker localization, and F-actin content, suggesting a role in inflammation regulation.

The sialidase NEU3 promotes pulmonary fibrosis in mice

This study shows that NEU3 sialidase is necessary and sufficient for pulmonary fibrosis in mice, with its enzymatic activity driving inflammation and fibrosis.

Serum Amyloid P inhibits single stranded RNA-induced lung inflammation, lung damage, and cytokine storm in mice

This study shows that serum amyloid P (SAP) reduces lung inflammation, damage, and cytokine storm in a mouse model of COVID-19-like symptoms induced by ssRNA.