R. Rijal

PTEN and the PTEN-like phosphatase CnrN have both distinct and overlapping roles in a Dictyostelium chemorepulsion pathway

This study investigates the distinct and overlapping roles of PTEN and CnrN in Dictyostelium chemorepulsion by analyzing their effects on phosphoinositide levels and cell behavior.

Gallein and isoniazid act synergistically to attenuate Mycobacterium tuberculosis growth in human macrophages

This study shows that gallein and isoniazid work together to reduce Mycobacterium tuberculosis growth in human macrophages by inhibiting polyphosphate accumulation.

Polyphosphate uses mTOR, pyrophosphate, and Rho GTPase components to potentiate bacterial survival in Dictyostelium

This paper identifies key components of the polyP signaling pathway in D. discoideum that inhibit bacterial killing, suggesting potential therapeutic targets for enhancing macrophage pathogen clearance.

Starvation induces extracellular accumulation of polyphosphate in Dictyostelium discoideum to inhibit macropinocytosis, phagocytosis, and exocytosis

This study shows that starvation in Dictyostelium discoideum increases extracellular polyphosphate, which inhibits macropinocytosis, phagocytosis, and exocytosis by reducing membrane fluidity.

Dictyostelium discoideum cells sense their local density and retain nutrients when the cells are about to overgrow their food source

This study shows that Dictyostelium discoideum cells use extracellular polyP to sense local density and inhibit nutrient exocytosis when food is about to be overgrown.