S. Jing

Modular Design and Scaffold-Synthesis of Multi-Functional Fluorophores for Targeted Cellular Imaging and Pyroptosis

This study designs and synthesizes functional fluorophores using a scaffold-based Ugi reaction, enabling detection of reactive-oxygen species and controlled subcellular localization, with some compounds showing pyroptosis-inducing activity in cancer cells.

A mutation-mediated host shift drives Avian paramyxovirus type 1 evolution

This study identifies mutations in the P protein of Avian paramyxovirus type 1 that drive host shift from chickens to pigeons through enhanced degradation of LSm14A.

Polyphosphate uses mTOR, pyrophosphate, and Rho GTPase components to potentiate bacterial survival in Dictyostelium

This paper identifies key components of the polyP signaling pathway in D. discoideum that inhibit bacterial killing, suggesting potential therapeutic targets for enhancing macrophage pathogen clearance.

Starvation induces extracellular accumulation of polyphosphate in Dictyostelium discoideum to inhibit macropinocytosis, phagocytosis, and exocytosis

This study shows that starvation in Dictyostelium discoideum increases extracellular polyphosphate, which inhibits macropinocytosis, phagocytosis, and exocytosis by reducing membrane fluidity.

Wireless closed-loop smart bandage for chronic wound management and accelerated tissue regeneration

This paper develops a wireless smart bandage that monitors wound conditions and delivers electrical stimulation to accelerate tissue regeneration in chronic wounds.

Neuropilin-1 Mediates SARS-CoV-2 Infection in Bone Marrow-derived Macrophages

This study shows SARS-CoV-2 infects bone marrow-derived macrophages via neuropilin-1, not ACE2, and affects osteoclast function.

A Deep Learning Pipeline for Nucleus Segmentation

This paper develops a deep learning pipeline to evaluate nuclear segmentation models trained on small, custom annotated datasets, showing they can match or exceed performance of pre-trained models.

In Vitro Potent Activity of ε-poly-L-lysine against Candida albicans and the Underlying Mechanisms

This study investigates the antifungal activity of ε-poly-L-lysine against Candida albicans planktonic cells and biofilms, finding it inhibits growth, disrupts morphogenesis, and induces oxidative stress.

Immunogenicity and protective potency of Norovirus GII.17 virus-like particle-based vaccine

This study demonstrates that GII.17 virus-like particles (VLPs) can be produced and show protective potency against NoV GII.17 infection by blocking saliva histo-blood group antigen binding.