R. Voituriez

Aging and freezing of active nematic dynamics of cancer-associated fibroblasts by fibronectin matrix remodeling

This study investigates how fibronectin matrix remodeling by cancer-associated fibroblasts (CAFs) influences their nematic dynamics, revealing aging and freezing of defect motion in the ECM.

Polarization and motility of one-dimensional multi-cellular trains

The paper models one-dimensional multi-cellular migration, showing that cell-cell interactions lead to multiple motility modes and that MDCK cells operate near a balance between Contact Inhibition of Locomotion and Cryptic Lamellipodia.

Advected percolation in the actomyosin cortex drives amoeboid cell motility

The paper identifies advected percolation as a mechanism driving amoeboid cell motility by analyzing actin cortex dynamics in motile blebs.

Elasticity of dense actin networks produces nanonewton protrusive forces

The paper investigates how dense actin networks in podosomes generate protrusive forces by combining cryo-electron tomography and theoretical modeling.

Cytoplasmic forces functionally reorganize nuclear condensates in oocytes

This study shows that cytoplasmic forces reorganize nuclear condensates in oocytes, affecting mRNA processing and meiotic divisions.

Cell motility driven by long-lived spatial memory

This study shows cells retain memory of their path through physicochemical footprints, leading to self-interacting random walks and altered space exploration.

Cell clusters adopt a collective amoeboid mode of migration in confined non-adhesive environments

The paper shows that cell clusters can migrate in a collective amoeboid mode without adhesion, relying on supracellular contractility rather than traction forces.

Centering based on active diffusion in mouse oocytes is non-specific

The paper investigates nucleus centering in mouse oocytes and finds that an activity gradient induces a general centering force through biased diffusion, which is counteracted by myosin-dependent spindle off-centering.

Adhesion-free cell migration by topography-based force transduction

This study shows leukocytes can migrate without adhesion by using substrate topography to transduce force from actin retrograde flow.

Cell motion as a stochastic process controlled by focal contacts dynamics.

This study shows how focal contact dynamics and spatial distribution control cell directionality through a ratchetaxis mechanism, leading to quantitative predictions of cell motion.

Actomyosin-driven force patterning controls endocytosis at the immune synapse

This study shows that mechanical forces at the immune synapse are spatially and temporally patterned by actomyosin dynamics, with global contractile forces at the periphery and local forces at the center, which regulate endocytosis.

Stick-slip dynamics of cell adhesion triggers spontaneous symmetry breaking and directional migration

Cells break symmetry through mechanical instabilities causing stochastic adhesion detachment, initiating migration without pre-established polarity.

Active fluctuations modulate gene expression in mouse oocytes

The paper shows that nucleus positioning in mouse oocytes affects gene expression and chromatin dynamics through F-actin-mediated mechanical forces.

Macropinocytosis overcomes directional bias due to hydraulic resistance to enhance space exploration by dendritic cells

This study shows that macropinocytosis enables immature dendritic cells to overcome hydraulic resistance, enhancing their space exploration and tissue-patrolling function, while mature dendritic cells are hindered by this resistance.