Author

O. Thorn-Seshold

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell signaling & trafficking· 6 Research Focus:cell type annotation· 4 Research Focus:drug response / drug discovery· 3 Research Focus:development & morphogenesis· 2 Assay:imaging· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

C. Heise· 4 shared A. Akhmanova· 3 shared J. C. M. Meiring· 3 shared J. Thorn-Seshold· 3 shared L. Gao· 3 shared D. Trauner· 2 shared M. O. Steinmetz· 2 shared M. Wranik· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCell Biology

C. Heise

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Cyclic dichalcogenides extend the reach of bioreductive prodrugs to harness the thioredoxin system: applications to seco-duocarmycins

J. G. Felber, A. Kitowski, L. Zeisel, M. S. Maier, C. Heise, J. Thorn-Seshold, O. Thorn-Seshold

This paper introduces a new class of bioreductive prodrugs activated by the thioredoxin system, showing in vivo efficacy against breast and pancreatic cancer.

bioRxiv · Nov 11, 2022Biochemistry

Next Generation Opto-Jasplakinolides Enable Local Remodeling of Actin Networks

F. Küllmer, N. A. Veprek, M. Borowiak, V. Nasufovic, S. Barutzki, O. Thorn-Seshold, H.-D. Arndt, D. H. Trauner

This paper introduces a new generation of optojasplakinolides with improved photoswitching properties for precise control of actin dynamics in live cells.

bioRxiv · Feb 21, 2022Cell Biology

Photoswitchable epothilone-based microtubule stabilisers allow GFP imaging-compatible, optical control over the microtubule cytoskeleton

L. Gao, J. C. M. Meiring, C. Heise, A. Rai, A. Mueller-Deku, A. Akhmanova, J. Thorn-Seshold, O. Thorn-Seshold

This paper introduces photoswitchable epothilone reagents (STEpos) that allow optical control over microtubule stability and dynamics with high spatiotemporal precision.

bioRxiv · Mar 31, 2021Cell Biology

In vivo photocontrol of microtubule dynamics and integrity, migration and mitosis, by the potent GFP-imaging-compatible photoswitchable reagents SBTubA4P and SBTub2M

L. Gao, J. C. M. Meiring, A. Varady, I. E. Ruider, C. Heise, M. Wranik, C. D. Velasco, J. A. Taylor, B. Terni, J. Standfuss, C. C. Cabernard, A. Llobet, M. O. Steinmetz, A. R. Bausch, M. Distel, , O. Thorn-Seshold

This paper introduces two new photoswitchable reagents for in vivo control of microtubule dynamics and related processes, showing their effectiveness in 3D systems and model organisms.

bioRxiv · Mar 26, 2021Cell Biology

Photoswitchable microtubule stabilisers optically control tubulin cytoskeleton structure and function

A. Müller-Deku, K. Loy, Y. Kraus, C. Heise, R. Bingham, J. Ahlfeld, D. Trauner, O. Thorn-Seshold

The paper develops photoswitchable microtubule stabilizers that allow optical control of microtubule structure and function in live cells with high spatiotemporal precision.

bioRxiv · Sep 23, 2019Cell Biology

Photoswitchable microtubule inhibitors enabling robust, GFP-orthogonal optical control over the tubulin cytoskeleton

L. Gao, Y. Kraus, M. Wranik, T. Weinert, S. D. Pritzl, J. C. M. Meiring, R. Bingham, N. Olieric, A. Akhmanova, T. Lohmüller, M. O. Steinmetz, O. Thorn-Seshold

The paper introduces photoswitchable microtubule inhibitors that enable optical control over microtubule dynamics using a novel scaffold with improved chemical and biochemical properties.

bioRxiv · Jul 28, 2019Cell Biology

Microtubules control cellular shape and coherence in amoeboid migrating cells

A. Kopf, J. Renkawitz, R. Hauschild, I. Girkontaite, K. Tedford, J. Merrin, O. Thorn-Seshold, D. Trauner, H. Haecker, K. D. Fischer, E. Kiermaier, M. Sixt

This study shows that microtubules regulate protrusion retraction in migrating cells by controlling myosin II contractility through Lfc, maintaining cell shape and coherence.

bioRxiv · Jul 23, 2019Cell Biology