Therapeutic blockade of Activin-A improves NK cell function and anti-tumor immunity
J. Rautela, L. F. Dagley, I. S. Schuster, S. Hediyeh-Zadeh, R. Delconte, J. Cursons, R. Hennessy, D. S. Hutchinson, C. Harrison, C. C. Oliveira, E. Vivier, A. I. Webb, M. Degli-Esposti, M. Davis, N. D. Huntington, F. Souza-Fonseca-Guimaraes
This study shows Activin-A inhibits NK cell function, promotes transdifferentiation into ILC1-like cells, and suppresses anti-tumor immunity, with therapeutic blockade improving outcomes.
bioRxiv · Oct 29, 2018 · PreprintImmunology