Author

J. Rautela

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

N. Huntington· 2 shared S. L. Nutt· 2 shared A. M. Lew· 1 shared A. Madhumalar· 1 shared A. P. Ng· 1 shared A. Tasneem· 1 shared C. Chauhan· 1 shared C. D. Hyland· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCell Biology

N. Huntington

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CD45 limits Natural Killer cell development from common lymphoid progenitors

L. G. Meza Guzman, C. D. Hyland, G. M. Bidgood, E. Leong, Z. Shen, W. Goh, T. Kratina, J. Rautela, J. Vince, S. Nicholson, N. Huntington

This study shows that CD45 deficiency in common lymphoid progenitors causes NK cell developmental defects, not enhanced persistence, suggesting CD45 inhibition could improve in vitro NK cell generation for therapy.

bioRxiv · Apr 17, 2023 · PreprintCell Biology

CIS calibrates GM-CSF signalling strength to regulate macrophage polarization via a STAT5-IRF8 axis

s. zhang, J. Rautela, N. G. Bediaga, T. Kolesnik, Y. You, L. Dagley, J. Bedo, H. Wang, L. Sun, R. Sutherland, E. Surgenor, N. Iannarella, R. S. Allan, F. Souza-Fonseca-Guimaraes, Y. Xie, , Y. Zhan

This study identifies CIS as a regulator of GM-CSF signaling that controls macrophage polarization via the STAT5-IRF8 axis, influencing immune responses and allergic inflammation.

bioRxiv · Mar 31, 2022 · PreprintImmunology

Peracetyl N-cyclobutanoyl-D-mannosamine enhances expression of sialyl-Lewis X (sLeX / CD15s) and adhesion of leukocytes

A. Tasneem, S. Parashar, S. Aittan, T. Jain, C. Chauhan, J. Rautela, Z. A. Bhat, K. Raza, A. Madhumalar, S.-G. Sampathkumar

This paper shows that Ac4ManNCb increases sLeX expression and leukocyte adhesion by altering sLeX conformations through molecular dynamics simulations.

bioRxiv · Dec 22, 2021 · PreprintBiochemistry

The clonal and molecular aetiology of emergency dendritic cell development

D. S. Lin, L. Tian, S. Tomei, D. Amann-Zalcenstein, T. M. Baldwin, T. S. Weber, J. Schreuder, O. Stonehouse, J. Rautela, N. D. Huntington, A. P. Ng, S. L. Nutt, S. Taoudi, M. E. Ritchie, P. D. Hodgkin, S. H. Naik

This study investigates Flt3L-driven emergency dendritic cell development, revealing clonal expansion and molecular mechanisms in HSPCs leading to cDC1 generation.

bioRxiv · May 28, 2020 · PreprintImmunology