K. Ahmed

Analysis of differential expression of matrix metalloproteins and defensins in the nasopharyngeal milieu of mild and severe COVID-19 cases

This study compares MMP and defensin expression in mild and severe COVID-19 cases to identify associations with disease severity.

BCG activation of trained immunity is associated with induction of cross reactive COVID-19 antibodies in a BCG vaccinated population.

The study examines BCG-induced trained immunity in adults, finding elevated cytokine responses and cross-reactive SARS-CoV-2 antibodies, suggesting potential cross-protection against COVID-19.

Mesothelial cells exhibit characteristics of perivascular cells in an in vitro angiogenesis assay

This study shows mesothelial cells can adopt a perivascular phenotype and support angiogenesis in vitro by aligning with endothelial networks and upregulating pericyte markers.

Omicron BA.1 and BA.2 neutralizing activity elicited by a comprehensive panel of human vaccines

This study evaluates neutralizing activity against Omicron BA.1 and BA.2 variants elicited by various vaccines and finds that booster doses enhance neutralizing titers and breadth across all vaccine platforms.

SARS-CoV-2 spike conformation determines plasma neutralizing activity

This study shows that vaccines encoding a prefusion-stabilized SARS-CoV-2 spike protein induce higher neutralizing antibody titers and better variant cross-neutralization compared to other vaccines or infection.

Harnessing tumor immune ecosystem dynamics to personalize radiotherapy

This study uses a computational model to analyze tumor immune ecosystem dynamics and predict how radiotherapy affects immune responses in lung cancer patients.

Hyperactive TORC1 sensitizes yeast cells to endoplasmic reticulum stress by compromising cell wall integrity

This study shows that hyperactive TORC1 in yeast increases sensitivity to ER and cell wall stress by compromising cell wall integrity, suggesting potential for antifungal drug targets.