Author

R. Jakhar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

K. Sachaphibulkij· 2 shared L. H. K. Lim· 2 shared A. D. Jeyasekharan· 1 shared A. K. Gao· 1 shared A. Shendre· 1 shared B. V. Au· 1 shared B. W. Q. Tan· 1 shared C. Frezza· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

K. Sachaphibulkij

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Tumour-derived extracellular vesicles within the therapy-induced senescent secretome distinctly suppress breast cancer via DKK1-mediated inflammatory response.

M. Robert, R. Jakhar, B. V. Au, G. W. L. Eng, M. Wei, A. K. Gao, Y. H. Chuah, K. Sachaphibulkij, I. Bonne, K. J. Lim, I. Sinha, D. B. L. Teh, L. H. K. Lim, P. Kumar, N. K. Verma, , K. C. Crasta

This study identifies that TIS-derived extracellular vesicles suppress breast cancer through DKK1-mediated inflammation, contrasting with the pro-tumorigenic effects of the senescence-associated secretome.

bioRxiv · Mar 29, 2024 · PreprintCancer Biology

PLK1 inhibition selectively kills ARID1A deficient cells through uncoupling of oxygen consumption from ATP production

U. S. Srinivas, G. K. Ramachandran, J. D. Wardyn, M. M. Hoppe, Y. Peng, S. Lim, M. Y. Lee, P. C. Peethala, O. An, A. Shendre, B. W. Q. Tan, T. S. C. Norbert, P. Jaynes, L. Hu, R. Jakhar, , A. D. Jeyasekharan

This study identifies ARID1A deficiency as a biomarker for PLK1 inhibitor sensitivity by revealing a mitochondrial metabolic vulnerability in these cells.

bioRxiv · Jun 1, 2021 · PreprintCancer Biology