Author

L. H. K. Lim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

K. Sachaphibulkij· 2 shared A. Cazenave-Gassiot· 1 shared A. D. Jeyasekharan· 1 shared A. Shendre· 1 shared B. Halliwell· 1 shared B. W. Q. Tan· 1 shared C. Frezza· 1 shared D. Kappei· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersPhysiology

K. Sachaphibulkij

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mfsd7b facilitates choline uptake and missense mutations affect choline transport function

T. T. H. Ha, V. K. Sukumar, J. W. B. Chua, D. T. Nguyen, T. Q. Nguyen, L. H. K. Lim, A. Cazenave-Gassiot, L. N. Nguyen

This study identifies MFSD7b as a choline transporter and shows that missense mutations impair its function.

bioRxiv · Sep 30, 2023 · PreprintBiochemistry

Protection against doxorubicin-induced cardiotoxicity by ergothioneine

I. K. Cheah, R. M. Y. Tang, X. Wang, K. Sachaphibulkij, S. Y. Chong, L. H. K. Lim, J.-W. Wang, B. Halliwell

This study investigates ergothioneine's protective effects against doxorubicin-induced cardiotoxicity in mice and finds it significantly reduces cardiac dysfunction without affecting tumor growth or chemotherapy efficacy.

bioRxiv · Dec 21, 2022Physiology

PLK1 inhibition selectively kills ARID1A deficient cells through uncoupling of oxygen consumption from ATP production

U. S. Srinivas, G. K. Ramachandran, J. D. Wardyn, M. M. Hoppe, Y. Peng, S. Lim, M. Y. Lee, P. C. Peethala, O. An, A. Shendre, B. W. Q. Tan, T. S. C. Norbert, P. Jaynes, L. Hu, R. Jakhar, , A. D. Jeyasekharan

This study identifies ARID1A deficiency as a biomarker for PLK1 inhibitor sensitivity by revealing a mitochondrial metabolic vulnerability in these cells.

bioRxiv · Jun 1, 2021 · PreprintCancer Biology