Author

O. An

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:differential expression· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

H. Yang· 5 shared L. Chen· 2 shared P. Tan· 2 shared W. J. Chng· 2 shared W. P. Yong· 2 shared Y. Song· 2 shared A. D. Jeyasekharan· 1 shared A. Shendre· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersCancer Biology

H. Yang

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Exploring the Neoantigen burden in Breast Carcinoma Patients

S. Animesh, X. Ren, O. An, K. Chen, S. C. Lee, H. Yang, M. Fullwood

This study analyzes neoantigen burden in breast cancer patients using whole-exome and RNA sequencing, finding high patient-specificity and correlation with somatic mutations.

bioRxiv · Mar 3, 2022 · PreprintCancer Biology

ADAR2-repressed RNA editing: a novel mechanism contributing to t (8:21) AML leukemogenesis

M. Guo, T. H. M. Chan, O. An, Y. Song, Z. H. Tan, V. H. E. Ng, X. Cao, W. J. Chng, M. Osato, H. Yang, Q. Zhou, L. Chen, D. G. Tenen

This study identifies ADAR2 downregulation in t(8;21) AML and shows its role in suppressing leukemogenesis through RNA editing.

bioRxiv · Oct 18, 2021 · PreprintCancer Biology

PLK1 inhibition selectively kills ARID1A deficient cells through uncoupling of oxygen consumption from ATP production

U. S. Srinivas, G. K. Ramachandran, J. D. Wardyn, M. M. Hoppe, Y. Peng, S. Lim, M. Y. Lee, P. C. Peethala, O. An, A. Shendre, B. W. Q. Tan, T. S. C. Norbert, P. Jaynes, L. Hu, R. Jakhar, , A. D. Jeyasekharan

This study identifies ARID1A deficiency as a biomarker for PLK1 inhibitor sensitivity by revealing a mitochondrial metabolic vulnerability in these cells.

bioRxiv · Jun 1, 2021 · PreprintCancer Biology

Generation of human chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseases

B. X. Ho, J. Pang, Q. H. Phua, L. C. Liew, B. M. Poh, Y. Chen, Y.-H. Loh, O. An, H. H. Yang, V. P. Seshachalam, J. L. Koh, W.-K. Chan, S.-Y. Ng, B.-S. Soh

This study generates human chambered cardiac organoids from pluripotent stem cells to model cardiac hypertrophy and improve cardiovascular disease research.

bioRxiv · May 21, 2021 · PreprintCell Biology

"3G" Trial: An RNA Editing Signature for Guiding Gastric Cancer Chemotherapy

O. An, Y. Song, X. Ke, J. B.-Y. So, R. Sundar, H. Yang, S. Y. Rha, L. M. Hui, T. S. Ting, O. X. Wen, A. T. L. Keng, M. C. H. Ng, E. Tantoso, L. Chen, P. Tan, , Singapore Gastric Cancer Consortium (SGCC)

The paper develops an RNA editing signature (GCRE) to predict chemotherapy response in gastric cancer, achieving 84% accuracy and showing better outcomes in patients with higher editing levels.

bioRxiv · Jun 22, 2020Cancer Biology

Three-dimensional Genome Organization Maps in Normal Haematopoietic Stem Cells and Acute Myeloid Leukemia

B. Wang, L. Kong, D. Babu, R. Choudhary, W. Fam, J. Q. Tng, Y. Goh, B. Wong Jern Han, X. Liu, F. F. Song, P. Chia, M. C. Chan, O. An, C. Y. Tham, T. Benoukraf, , M. J. Fullwood

This study maps 3D genome organization in normal and AML haematopoietic stem cells, finding increased chromatin loops to oncogenes in AML and identifying MEIS1 and HOXA9 as key oncogenes regulated by these interactions.

bioRxiv · Apr 18, 2020 · PreprintCancer Biology