N. McGranahan

RNA allelic frequencies of somatic mutations encode substantial functional information in cancers

This study uses RNA variant allele frequencies to identify cancer genes with RVdriver, showing it can detect both known and novel cancer genes with performance comparable to DNA-based methods.

Genomic evolution of non-small cell lung cancer patient-derived xenograft models

This study examines how well PDX models capture intratumour heterogeneity in NSCLC, finding that most models originate from a single subclone but regional models can capture diversity.

Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer

This study characterizes clinical and molecular features of acquired resistance to PD-(L)1 blockade in NSCLC, identifying persistent inflammation and dysfunctional IFN signaling as key features.

Somatic chromosomal number alterations affecting driver genes inform in-vitro and clinical drug response in high-grade serous ovarian cancer

This study shows that somatic copy number alterations in driver genes correlate with drug response in HGSOC spheroid models and clinical settings.

Immune surveillance in clinical regression of pre-invasive squamous cell lung cancer

The paper investigates immune surveillance in pre-invasive squamous cell lung cancer, finding that regressive lesions have more immune infiltration and distinct molecular profiles compared to progressive lesions.

Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner

This study shows that homozygous PIK3CAH1047R mutations in iPSCs lead to cancer-like changes, while heterozygous mutations do not, highlighting allele dose-dependent effects.

Plk1 overexpression suppresses tumor development by inducing chromosomal instability

This study shows that Plk1 overexpression suppresses tumor development by causing chromosomal instability and cytokinesis defects, despite its role as an oncogene.