Brown adipocyte NOSEMPE promotes nonmitochondrial thermogenesis and improves systemic metabolism through ATF4 activation
E. Paulo, Y. Zhang, R. Masand, T. L. Huynh, Y. Seo, D. L. Swaney, M. Soucheray, D. Jimenez-Morales, N. J. Krogan, B. Wang
The paper identifies NOSEMPE in brown adipocytes as a cause of mitochondrial ETC imbalance and shows it drives nonmitochondrial thermogenesis and metabolic improvement via ATF4 activation.
bioRxiv · Apr 16, 2019 · PreprintPhysiology