Senescence rewires microenvironment sensing to facilitate anti-tumor immunity
H.-A. Chen, Y.-J. Ho, R. Mezzadra, J. M. Adrover, R. M. Smolkin, C. Zhu, L. Wei, A. Wuest, S. Tian, X. Li, R. C. Hendrickson, M. Egeblad, D. Alonso-Curbelo, S. W. Lowe
The paper shows senescent cells enhance immune surveillance by remodeling their surface proteome to better sense and respond to environmental signals like IFN-gamma.
bioRxiv · Jun 4, 2022Cancer Biology