Author

D. Alonso-Curbelo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell-cell communication· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. Pe'er· 3 shared F. M. Barriga· 3 shared R. Chaligne· 3 shared S. W. Lowe· 3 shared Y.-J. Ho· 3 shared A. N. Wuest· 2 shared A. Wuest· 2 shared C. A. Iacobuzio-Donahue· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

D. Pe'er

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Metastatic site influences driver gene function in pancreatic cancer

K. M. Tsanov, F. M. Barriga, Y.-J. Ho, D. Alonso-Curbelo, G. Livshits, R. P. Koche, T. Baslan, J. Simon, S. Tian, A. N. Wuest, W. Luan, J. E. Wilkinson, I. Masilionis, N. Dimitrova, C. A. Iacobuzio-Donahue, , S. W. Lowe

This study shows that metastatic site influences the function of driver genes like SMAD4 in pancreatic cancer, with organ-specific epigenetic states affecting tumor growth.

bioRxiv · Mar 17, 2024 · PreprintCancer Biology

Chromosome 9p21.3 Coordinates Cell Intrinsic and Extrinsic Tumor Suppression

S. Lowe, F. M. Barriga, K. M. Tsanov, Y. J. Ho, N. Sohail, A. Zhang, T. Baslan, A. N. Wuest, I. Del Priore, B. Meskauskaite, G. Livshits, D. Alonso-Curbelo, J. Simon, A. Chaves-Perez, D. Bar-Sagi, , D. Pe'er

The paper investigates how 9p21.3 deletions in cancer disable both cell intrinsic and extrinsic tumor suppression by co-deleting CDKN2A/B and type I interferons, leading to immune evasion and metastasis.

bioRxiv · Aug 22, 2022 · PreprintCancer Biology

Epigenetic plasticity cooperates with emergent cell-cell interactions to drive neoplastic tissue remodeling in the pancreas

C. Burdziak, D. Alonso-Curbelo, T. Walle, F. M. Barriga, J. Reyes, Y. Xie, Z. Zhao, C. J. Zhao, H.-A. Chen, O. Chaudhary, I. Masilionis, Z.-N. Choo, V. Gao, W. Luan, A. Wuest, , D. Pe'er

The paper uses single-cell analysis to show that epigenetic plasticity and cell-cell interactions drive tissue remodeling in early pancreatic cancer.

bioRxiv · Jul 26, 2022Cancer Biology

Senescence rewires microenvironment sensing to facilitate anti-tumor immunity

H.-A. Chen, Y.-J. Ho, R. Mezzadra, J. M. Adrover, R. M. Smolkin, C. Zhu, L. Wei, A. Wuest, S. Tian, X. Li, R. C. Hendrickson, M. Egeblad, D. Alonso-Curbelo, S. W. Lowe

The paper shows senescent cells enhance immune surveillance by remodeling their surface proteome to better sense and respond to environmental signals like IFN-gamma.

bioRxiv · Jun 4, 2022Cancer Biology

Antimetastatic dsRNA mimics identified by live imaging of pathogenic neolymphangiogenesis

D. Olmeda, D. Cerezo-Wallis, T. G. Calvo, D. Alonso-Curbelo, E. Canon, N. Ibartz, J. Munoz, S. Ortega, M. S. Soengas

The paper identifies dsRNA mimics as inhibitors of lymphangiogenesis and metastasis using live imaging models of melanoma.

bioRxiv · Dec 26, 2019 · PreprintCancer Biology

An in vivo KRAS allelic series reveals distinct phenotypes of common oncogenic variants

M. P. Zafra, D. Alonso-Curbelo, S. Goswami, E. M. Schatoff, T. Han, J. E. Wilkinson, L. E. Dow

The paper creates KRAS mutant mouse models to study how different oncogenic variants affect tumor development and therapy response in vivo.

bioRxiv · Nov 20, 2019Cancer Biology