R. C. Hendrickson

β2 integrins impose a mechanical checkpoint on macrophage phagocytosis

This study shows that β2 integrins regulate macrophage phagocytosis based on cargo rigidity, acting as a mechanical checkpoint to control engulfment strategies.

A CANCER PERSISTENT DNA REPAIR CIRCUIT DRIVEN BY MDM2, MDM4 (MDMX), AND MUTANT P53 FOR RECRUITMENT OF MDC1 AND 53BP1 TO CHROMATIN

This study identifies a cancer persistent DNA repair circuit involving mtp53, MDM2, and MDMX that recruits 53BP1 and MDC1 to chromatin, enhancing cell survival.

Enhanced methionine cycle suppresses naïve CD8+ T-cell maturation

This study identifies an accelerated methionine cycle in immature CD8+ T cells that suppresses their maturation and immune response, showing that inhibiting the cycle promotes maturation and immune recovery.

Senescence rewires microenvironment sensing to facilitate anti-tumor immunity

The paper shows senescent cells enhance immune surveillance by remodeling their surface proteome to better sense and respond to environmental signals like IFN-gamma.

Vaccinia E5 is a major inhibitor of the DNA sensor cGAS

This study identifies Vaccinia E5 as a major inhibitor of the cGAS-STING pathway by promoting cGAS degradation through proteasome-dependent ubiquitination.

ERα-LBD, a novel isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance

The paper identifies ER-LBD, a novel estrogen receptor alpha isoform, which promotes breast cancer growth and resistance to endocrine therapy.

LncRNA Miat and Metadhedrin maintain a treatment resistant stem-like niche of medulloblastoma cells

This study identifies Miat and Metadhedrin as key regulators of treatment-resistant stem-like medulloblastoma cells, showing their role in maintaining a therapy-resistant niche.

Anti-tumor effects of an Id antagonist with no acquired resistance

This study demonstrates that AGX51, an Id antagonist, effectively inhibits tumor growth in multiple cancer models without inducing acquired resistance.

DHTKD1 and OGDH display in vivo substrate overlap and form a hybrid ketoacid dehydrogenase complex

The paper shows DHTKD1 and OGDH share in vivo substrate overlap and form a hybrid ketoacid dehydrogenase complex, with implications for GA1 therapy.