Author

H.-A. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Wuest· 3 shared S. W. Lowe· 3 shared Y.-J. Ho· 3 shared D. Alonso-Curbelo· 2 shared S. Tian· 2 shared C. Amor· 1 shared C. Burdziak· 1 shared C. J. Zhao· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCancer Biology

A. Wuest

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Epigenetic plasticity cooperates with emergent cell-cell interactions to drive neoplastic tissue remodeling in the pancreas

C. Burdziak, D. Alonso-Curbelo, T. Walle, F. M. Barriga, J. Reyes, Y. Xie, Z. Zhao, C. J. Zhao, H.-A. Chen, O. Chaudhary, I. Masilionis, Z.-N. Choo, V. Gao, W. Luan, A. Wuest, , D. Pe'er

The paper uses single-cell analysis to show that epigenetic plasticity and cell-cell interactions drive tissue remodeling in early pancreatic cancer.

bioRxiv · Jul 26, 2022Cancer Biology

Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease

J. Leibold, C. Amor, K. M. Tsanov, Y.-J. Ho, F. J. Sanchez-Rivera, J. Feucht, T. Baslan, H.-A. Chen, S. Tian, J. Simon, A. Wuest, J. E. Wilkinson, S. W. Lowe

This study develops somatic mouse models of gastric cancer that replicate human disease subtypes and reveal genotype-specific metastatic patterns and immune interactions.

bioRxiv · Jun 15, 2022Cancer Biology

Senescence rewires microenvironment sensing to facilitate anti-tumor immunity

H.-A. Chen, Y.-J. Ho, R. Mezzadra, J. M. Adrover, R. M. Smolkin, C. Zhu, L. Wei, A. Wuest, S. Tian, X. Li, R. C. Hendrickson, M. Egeblad, D. Alonso-Curbelo, S. W. Lowe

The paper shows senescent cells enhance immune surveillance by remodeling their surface proteome to better sense and respond to environmental signals like IFN-gamma.

bioRxiv · Jun 4, 2022Cancer Biology