R. O. Pereira

This study shows ATF4 is essential for cold-induced thermogenesis in mice through amino acid metabolism, independent of FGF21, while FGF21 is not required for thermoregulation.

This study identifies GDF15 as a mediator of improved metabolic health and thermogenesis in OPA1-deficient brown adipocytes, showing its role in glucose homeostasis and cold-induced thermogenesis.

This study shows that OPA1 deficiency in skeletal muscle increases MERC formation via ATF4, affecting calcium exchange and mitochondrial-ER tethering.

This paper describes methods to identify and distinguish subcellular structures involved in macroautophagy using TEM and 3D reconstruction, with applications to quantify degradation machinery under different conditions.

The paper introduces a standardized protocol using Amira software to quantify 3D organelle morphology from SBF-SEM data, demonstrating its application to mitochondria and ER structures.

This paper presents a method for preserving and quantitatively measuring mitochondrial morphology in tissues and cultured cells without introducing artifacts.

This paper introduces a standardized method using ImageJ to quantify subcellular organelle morphology in TEM images, focusing on mitochondria, ER, lysosomes, and autophagosomes.

This study shows that cardiac-specific overexpression of TFEB leads to pathologic hypertrophy and lethal cardiomyopathy through mitochondrial dysfunction and fibrosis.

This study shows that deleting OPA1 in brown adipose tissue enhances thermoregulation and metabolism through the ATF4-FGF21 pathway, independent of thermogenesis.