Author

T. A. Christensen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Cell Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 8 Assay:imaging· 6 Approach:experimental assay· 5 Approach:microscopy & imaging analysis· 3 Organism:mouse· 2 Research Focus:spatial domain detection· 2 Research Focus:clustering· 1 Research Focus:dimensionality reduction· 1

Frequent Co-Authors

K. Neikirk· 6 shared Z. Vue· 6 shared A. Hinton· 5 shared B. Glancy· 5 shared M. Mungai· 5 shared P. Katti· 5 shared E. D. Abel· 4 shared E. Garza Lopez· 4 shared

Activity by Year

2021-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersBiophysics

K. Neikirk

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Three-dimensional structure of inner ear hair cell mitochondrial networks and ribbon synapses in a zebrafish model of Usher syndrome type 1B

K. C. Riley, A. Koleilat, J. A. Dugdale, S. A. Cooper, T. A. Christensen, L. A. Schimmenti

This study uses 3D imaging to compare hair cell structures in wildtype and myo7aa-/- zebrafish, finding reduced ribbon synapse size but no other significant differences.

bioRxiv · Oct 1, 2022 · PreprintCell Biology

Three-Dimensional Mitochondria Reconstructions of Murine Cardiac Muscle Changes in Size Across Aging

Z. Vue, K. Neikirk, L. Vang, E. Garza-Lopez, T. A. Christensen, J.-q. Shao, J. Lam, H. K. Beasley, A. G. Marshall, A. Crabtree, J. Anudokem, B. Rodriguez, B. Kirk, S. Bacevac, T. Barongan, , A. Hinton

This study uses 3D imaging to show that mitochondria in aging mouse hearts lose cristae structure and volume, similar to mutations in MICOS complex genes.

bioRxiv · Apr 23, 2022Biophysics

3D Reconstruction of Murine Mitochondria Exhibits Changes in Structure Across Aging Linked to the MICOS Complex

Z. Vue, E. Garza-Lopez, K. Neikirk, P. Katti, L. Vang, H. K. Beasley, J.-q. Shao, A. G. Marshall, A. Crabtree, A. C. Murphy, B. C. Jenkins, P. Prasad, C. S. Evans, B. T. Taylor, M. Mungai, , Murray

This study examines age-related changes in mitochondrial 3D structure in mouse muscle and heart tissues, linking these changes to the MICOS complex and metabolic alterations.

bioRxiv · Mar 22, 2022Biophysics

Systematic Transmission Electron Microscopy-Based Identification and 3D Reconstruction of Cellular Degradation Machinery

K. Neikirk, Z. Vue, P. Katti, B. I. Rodriguez, S. A. Omer, J. Shao, T. A. Christensen, E. Garza Lopez, A. Marshall, C. Palavicino-Maggio, J. Ponce, A. Alghanem, L. Vang, T. Barongan, H. Beasley, , A. Hinton

This paper describes methods to identify and distinguish subcellular structures involved in macroautophagy using TEM and 3D reconstruction, with applications to quantify degradation machinery under different conditions.

bioRxiv · Sep 26, 2021Biophysics

Practices for Measuring 3D Organelle Morphology and Generating Surfaces with Amira

E. Garza Lopez, Z. Vue, P. Katti, K. Neikirk, M. Biete, J. Lam, H. Beasley, A. Marshall, T. Rodman, T. A. Christensen, J. L. Salisbury, L. Vang, M. Mungai, S. AshShareef, S. Murray, , A. Hinton

The paper introduces a standardized protocol using Amira software to quantify 3D organelle morphology from SBF-SEM data, demonstrating its application to mitochondria and ER structures.

bioRxiv · Sep 25, 2021Biophysics

Highly efficient SARS-CoV-2 infection of human cardiomyocytes: spike protein-mediated cell fusion and its inhibition

C. K. Navaratnarajah, D. R. Pease, P. Halfmann, B. Taye, A. Barkhymer, K. G. Howell, J. E. Charlesworth, T. A. Christensen, Y. Kawaoka, R. Cattaneo, J. W. Schneider, Boyd Rasmussen and Frank J. Secreto, Timothy J. Nelson (Director)

This paper shows SARS-CoV-2 efficiently infects human cardiomyocytes via spike protein-mediated fusion, which is inhibited by furin blockade.

bioRxiv · Jul 30, 2021Microbiology

A comprehensive approach for artifact-free sample preparation and assessment of mitochondrial morphology in tissue and cultured cells

A. Hinton, P. Katti, T. A. Christensen, M. Mungai, J. Shao, L. Zhang, S. Trushin, A. Alghanem, A. Jaspersen, R. E. Geroux, K. Neikirk, M. Biete, E. Garza Lopez, Z. Vue, H. Beasley, , E. D. Abel

This paper presents a method for preserving and quantitatively measuring mitochondrial morphology in tissues and cultured cells without introducing artifacts.

bioRxiv · Jun 27, 2021Cell Biology

A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ

J. Lam, P. Katti, M. Biete, M. Mungai, S. AshShareef, K. Neikirk, E. Garza Lopez, Z. Vue, T. A. Christensen, H. Beasley, T. Rodman, J. L. Salisbury, B. Glancy, R. O. Pereira, E. D. Abel, A. Hinton

This paper introduces a standardized method using ImageJ to quantify subcellular organelle morphology in TEM images, focusing on mitochondria, ER, lysosomes, and autophagosomes.

bioRxiv · May 27, 2021Biophysics