R. Owens

Assessing drug uptake and response differences in 2D and 3D cellular environments using stimulated Raman scattering microscopy

This study compares drug uptake and response in 2D and 3D cell cultures using SRS microscopy, finding that 3D spheroids show greater drug tolerance despite similar intracellular drug levels.

Recreating the Biological Steps of Viral Infection on a Bioelectronic Platform to Profile Viral Variants of Concern

This paper presents a bioelectronic platform that recreates viral infection steps to identify distinct fusion signatures of SARS-CoV-2 variants of concern.

Correlative microscopy reveals the nanoscale morphology of E. coli-derived supported lipid bilayers

The paper uses correlative AFM and SIM to characterize E. coli-derived supported lipid bilayers at the nanoscale, revealing their composition and interactions with membrane-binding proteins.

Architecture of cell-cell junctions in situ reveals a mechanism for bacterial biofilm inhibition

The paper reveals the structure and function of CdrA in Pseudomonas aeruginosa biofilms, showing how it mediates cell-cell interactions and how targeting it can inhibit biofilm formation.

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

This study develops a vaccine candidate using SpyCatcher technology to display the SARS-CoV-2 RBD, showing strong neutralizing antibody responses in mice and pigs.

Hallmarks of basidiomycete soft- and white-rot in wood-decay -omics data of Armillaria

This study compares transcriptomic and proteomic data of two Armillaria species to understand their wood-decay mechanisms, finding that saprotrophic A. cepistipes shows more extensive changes than pathogenic A. ostoyae.

The evolution of parasite host range in genetically diverse host populations

The study tests whether genetically diverse host populations select for parasites with broader host ranges, finding mixed support for this hypothesis.

The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleotide selectivity of PNPs

This paper characterizes the structural and kinetic properties of SmPNP2, a new PNP isoform from Schistosoma mansoni, revealing its ability to bind and catalyze both pyrimidines and purines with a unique binding mode.