Author

C. Conceicao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 4 Organism:human· 2 Organism:plant (other)· 2 Assay:bulk RNA-seq· 1 Organism:chicken / avian· 1 Assay:protein structure· 1

Frequent Co-Authors

D. Bailey· 5 shared N. Thakur· 5 shared D. Bialy· 3 shared I. Dietrich· 3 shared P. Hollinghurst· 3 shared P. Stevenson-Leggett· 3 shared S. Bhat· 3 shared A. Burman· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

D. Bailey

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Novel technology to develop non-transmissible live influenza virus vaccines through alterations in M2/M42 ion channel expression

D. Kapczynski, K. Segovia, K. Chrzastek, C. Conceicao, D. L. Suarez, L. Vervelde, P. Digard

This paper develops non-transmissible live influenza virus vaccines by altering M2/M42 ion channel expression, showing they protect against H5 HPAIV without transmission.

bioRxiv · Apr 11, 2023 · PreprintMicrobiology

The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells

X. Zhuang, S. Tsukuda, F. Wrensch, P. A. Wing, M. Schilling, J. M. Harris, H. Borrmann, S. B. Morgan, J. L. Cane, L. Mailly, N. Thakur, C. Conceicao, H. Sanghani, L. Heydmann, C. Bach, , J. A. McKeating

This study shows BMAL1 regulates ACE2 expression and SARS-CoV-2 entry in lung epithelial cells, with SR9009 reducing viral replication through circadian mechanisms.

bioRxiv · Mar 20, 2021Microbiology

A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice

A. Silva-Cayetano, W. S. Foster, S. Innocentin, S. Belij-Rammerstorfer, A. J. Spencer, O. T. Burton, S. Fra-Bido, J. L. Lee, N. Thakur, C. Conceicao, D. Wright, J. Barrett, N. Evans-Bailey, C. Noble, D. Bailey, , M. A. Linterman

This study shows that a booster dose of the ChAdOx1 nCoV-19 vaccine increases immune response in aged mice compared to a single dose.

bioRxiv · Oct 27, 2020Immunology

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

T. K. Tan, P. Rijal, R. Rahikainen, A. Keeble, L. Schimanski, S. Hussain, R. Harvey, J. Hayes, J. Edwards, R. McLean, V. Martini, M. Pedrera, N. Thakur, C. Conceicao, I. Dietrich, , R. Owens

This study develops a vaccine candidate using SpyCatcher technology to display the SARS-CoV-2 RBD, showing strong neutralizing antibody responses in mice and pigs.

bioRxiv · Aug 31, 2020Immunology

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

S. P. Graham, R. K. McLean, A. J. Spencer, S. Belij-Rammerstorfer, D. Wright, M. Ulaszewska, J. C. Edwards, J. W. P. Hayes, V. Martini, N. Thakur, C. Conceicao, I. Dietrich, H. Shelton, R. Waters, A. Ludi, , T. Lambe

This study evaluates the immunogenicity of single and booster doses of the ChAdOx1 nCoV-19 vaccine in mice and pigs, finding that a booster significantly enhances antibody responses, especially in pigs.

bioRxiv · Jun 20, 2020Immunology

The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins

C. Conceicao, N. Thakur, S. Human, J. T. Kelly, L. Logan, D. Bialy, S. Bhat, P. Stevenson-Leggett, A. Zagrajek, P. Hollinghurst, M. Varga, C. Tsirigoti, J. Hammond, H. J. Maier, E. Bickerton, , D. Bailey

This study shows SARS-CoV-2 Spike protein can bind to ACE2 receptors from multiple mammals, indicating broad host tropism and potential for zoonotic transmission.

bioRxiv · Jun 17, 2020Microbiology