M. Duan

Association study of Plasmodium falciparum Acetyl-CoA Synthetase Mutations S868G and V949I with antimalarial drugs

This study investigates the association of PfACAS mutations S868G and V949I with antimalarial drug resistance using whole-genome sequencing and CRISPR/Cas9-engineered parasites.

Discovery of a Heparan Sulfate Binding Domain in Monkeypox Virus H3 as an Anti-poxviral Drug Target Combining AI and MD Simulations

The paper identifies a conserved heparan sulfate binding domain in MPXV H3 using AI and MD simulations, validates its role in viral adhesion, and demonstrates a protein inhibitor that disrupts this interaction, inhibiting infection in vitro and in vivo.

Harmonic imaging for nonlinear detection of acoustic biomolecules

This study introduces harmonic xAM (HxAM) imaging to improve GV detection sensitivity and imaging depth in vivo.

Acetyl-CoA Synthetase Mutations S868G and V949I Do Not Confer Resistance to Antimalarial Drugs in vitro in Plasmodium falciparum.

This study investigates whether mutations in PfACAS confer antimalarial drug resistance by engineering parasite lines with these mutations and testing their drug susceptibility in vitro.

Ultrasonic reporters of calcium for deep tissue imaging of cellular signals

This paper introduces a genetically encoded ultrasonic calcium reporter (URoC) for noninvasive in vivo imaging of calcium signaling in mammals.

Pan-genome analysis of different morphotypes reveals genomic basis of Brassica oleracea domestication and differential organogenesis

This study constructs a pan-genome of Brassica oleracea to uncover genomic basis of domestication and organogenesis differences among morphotypes.

Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell Analyses

The study maps human bone marrow plasma cell heterogeneity using single-cell transcriptomics, revealing maturation pathways and molecular features of long-lived plasma cells.

A 4-bp natural deletion of maize Na+/H+ exchanger gene alters maize salt stress tolerance

This paper identifies a 4-bp deletion in the maize ZmSOS1 gene that causes salt sensitivity and develops a molecular marker to improve salt tolerance in breeding programs.

Dissecting the genetic basis of the heterosis of Y900, an elite super-hybrid rice

The paper identifies genetic and regulatory mechanisms underlying heterosis in the rice hybrid Y900 by analyzing genome and transcriptome data from its parental lines.

Response of Surface Water Quality Characteristics to Socio-economic Factors in Eastern-Central China

This study analyzes the impact of socio-economic factors on surface water quality at provincial boundaries in China, identifying key factors affecting water quality.

Maturation of Human Long-lived Plasma Cells Results in Resistance to Apoptosis by Transcriptional and Epigenetic Regulation

This study shows human blood ASCs undergo transcriptional and epigenetic changes in the BM microniche to become apoptotic-resistant LLPC.

Genomically mined acoustic reporter genes enable real-time in vivo monitoring of tumors and tumor-homing probiotics

The paper develops improved acoustic reporter genes for real-time in vivo tumor and therapeutic bacteria monitoring in mouse models.

Popularizing recombinant baculovirus-derived OneBac system for scaling-up production of all recombinant adeno-associated virus vector serotypes

This paper optimizes a baculovirus system to efficiently produce all rAAV serotypes 1-13, achieving high yields and scalability for research and therapeutic applications.

Genome sequencing sheds light on the contribution of structural variants to Brassica oleracea diversification

This study identifies structural variants in Brassica oleracea genomes that contribute to morphological divergence between cauliflower and cabbage.

Initial sample processing can influence the soil microbial metabarcoding surveys, revealed by Leucocalocybe mongolica fairy ring ecosystem

This study examines how soil preservation methods affect microbial community composition in fairy ring soil using metabarcoding, finding that temperature exposure alters bacterial abundance but not fungal composition.

Gatekeeper helix activates Golgi SM protein Sly1 and directly mediates close-range vesicle tethering

The paper identifies a gatekeeper helix in Sly1 that binds membranes to relieve autoinhibition and mediate close-range vesicle tethering in the early secretory pathway.

Golgi SM protein Sly1 promotes productive trans-SNARE complex assembly through multiple mechanisms

The paper identifies three mechanisms by which Sly1 enhances SNARE-mediated membrane fusion and shows that close-range tethering is crucial when cis-SNARE assembly competes.

Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis

The paper uses super-resolution imaging to show that chromatin structure decompacts and fragments during early cancer development, even before tumors form, and this change may improve cancer detection and risk assessment.

Impending regeneration failure of the IUCN Vulnerable Borneo ironwood (Eusideroxylon zwageri)

The study shows declining regeneration of Borneo ironwood due to seedling herbivory and aggregation, highlighting conservation needs.