Polarized localization of phosphatidylserine in endothelium regulates Kir2.1
C. A. Ruddiman, R. Peckham, M. A. Luse, Y. L. A. Chen, M. Kuppusamy, B. Corliss, P. J. Hall, C.-J. Lin, S. M. Peirce, S. K. Sonkusare, R. P. Mecham, J. E. Wagenseil, B. E. Isakson
The paper shows phosphatidylserine (PS) localizes to myoendothelial junctions (MEJs) in endothelium, inhibiting PIP2-mediated Kir2.1 activation to regulate vascular diameter.
bioRxiv · Aug 1, 2022Physiology