Author

S. K. Sonkusare

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Physiology· 3 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 5 Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:electrophysiology· 2

Frequent Co-Authors

B. E. Isakson· 3 shared C. A. Ruddiman· 2 shared M. Kuppusamy· 2 shared V. E. Laubach· 2 shared Y. L. Chen· 2 shared Z. Daneva· 2 shared A. Bazaz· 1 shared A. Islam· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersPhysiology

B. E. Isakson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Purinergic P2Y2 Receptor-Induced Activation of Endothelial TRPV4 Channels Mediates Lung Ischemia-Reperfusion Injury

M. Kuppusamy, H. Q. Ta, H. N. Davenport, A. Bazaz, A. Kulshrestha, Z. Daneva, Y.-L. Chen, P. W. Carrott, V. E. Laubach, S. K. Sonkusare

This study identifies the purinergic P2Y2 receptor as a mediator of lung ischemia-reperfusion injury by activating endothelial TRPV4 channels through extracellular ATP release via Panx1.

bioRxiv · May 29, 2023Physiology

Polarized localization of phosphatidylserine in endothelium regulates Kir2.1

C. A. Ruddiman, R. Peckham, M. A. Luse, Y. L. A. Chen, M. Kuppusamy, B. Corliss, P. J. Hall, C.-J. Lin, S. M. Peirce, S. K. Sonkusare, R. P. Mecham, J. E. Wagenseil, B. E. Isakson

The paper shows phosphatidylserine (PS) localizes to myoendothelial junctions (MEJs) in endothelium, inhibiting PIP2-mediated Kir2.1 activation to regulate vascular diameter.

bioRxiv · Aug 1, 2022Physiology

The polyanionic drug suramin neutralizes histones and prevents endotheliopathy

N. Villalba, A. M. Sackheim, M. A. Lawson, L. Haines, Y. L. Chen, S. K. Sonkusare, Y.-T. Ma, J. Li, D. Majumdar, B. A. Bouchard, J. E. Boyson, M. E. Poynter, M. T. Nelson, K. Freeman

This paper shows suramin neutralizes histones, preventing endothelial damage and improving vascular function in inflammatory conditions.

bioRxiv · Dec 9, 2021Immunology

Endothelial Pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure

Z. Daneva, M. Ottolini, Y. L. Chen, E. Klimentova, S. A. Shah, R. D. Minshall, C. I. Seye, V. E. Laubach, B. E. Isakson, S. K. Sonkusare

The paper shows endothelial Panx1-TRPV4 signaling via ATP and P2Y2R lowers pulmonary arterial pressure by reducing contractility.

bioRxiv · Mar 9, 2021Biochemistry

Endothelial alpha globin is a nitrite reductase

T. C. S. Keller, A. S. Keller, G. B. Broseghini-Filho, J. T. Butcher, H. R. Askew Page, A. Islam, Z. Y. Tan, L. J. DeLalio, C. Lechauve, S. D. Brooks, P. Sharma, K. Hong, W. Xu, A. S. Padilha, C. A. Ruddiman, , B. E. Isakson

This study shows endothelial alpha globin functions as a nitrite reductase to mediate hypoxia-induced vasodilation in resistance arteries.

bioRxiv · Feb 12, 2021Physiology