Author

R. Pedretti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

B. A. Nguyen· 2 shared L. Saelices· 2 shared P. Singh· 2 shared S. Afrin· 2 shared V. Singh· 2 shared A. Javed· 1 shared A. Lemoff· 1 shared A. T. Balana· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiophysics

B. A. Nguyen

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis

B. A. Nguyen, V. Singh, S. Afrin, P. Singh, M. Pekala, Y. Ahmed, R. Pedretti, J. Canepa, A. Lemoff, B. Kluve-Beckerman, P. Wydorski, F. Chhapra, L. Saelices

The paper uses cryo-EM to show that cardiac ATTRwt amyloid fibrils from four patients are structurally identical, supporting their consistent clinical presentation.

bioRxiv · Mar 8, 2024Biophysics

O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology

A. T. Balana, A.-L. Mahul-Mellier, B. A. Nguyen, M. Horvath, A. Javed, E. R. Hard, Y. Jasiqi, P. Singh, S. Afrin, R. Pedretti, V. Singh, V. M.-Y. Lee, K. C. Luk, L. Saelices, H. A. Lashuel, M. R. Pratt

This study shows that O-GlcNAc modification of α-Synuclein leads to amyloid fibrils with reduced seeding activity and pathology in Parkinson's disease models.

bioRxiv · Mar 7, 2023 · PreprintBiochemistry