Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium liver stage
K. Vijayan, R. Chandrasekaran, O. T. Trakhimets, S. L. Brown, N. Dambrauskas, M. Zuck, G. R. R. Visweswaran, A. Watson, A. Raappana, S. Carbonetti, L. Kelnhofer-Millevolte, E. K. K. Glennon, R. Postiglione, D. N. Sather, A. Kaushansky
This study shows non-neutralizing antibodies can reduce the effectiveness of neutralizing antibodies against Plasmodium CSP, impacting vaccine efficacy in malaria-exposed individuals.
bioRxiv · Sep 15, 2020Immunology