Author

R. Chandrasekaran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Bioengineering· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. Kaushansky· 2 shared A. Raappana· 2 shared A. Watson· 2 shared C. H. Arrowsmith· 2 shared D. N. Sather· 2 shared K. Vijayan· 2 shared M. Zuck· 2 shared N. Dambrauskas· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

A. Kaushansky

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Author profile →

6 papers

Recent·Most cited

Huntingtin is an RNA-binding protein and participates in NEAT1-mediated paraspeckles

M. Yadav, R. J. Harding, T. Li, X. Xu, T. Gall-Duncan, M. Khan, C. Ferrari Bardile, G. L. Sequiera, S. Duan, R. Chandrasekaran, A. Pan, J. Bu, T. Yamazaki, T. Hirose, P. Prinos, , C. H. Arrowsmith

This study identifies huntingtin as an RNA-binding protein that interacts with G-rich RNA sequences, including those in the NEAT1 paraspeckle lncRNA.

bioRxiv · Feb 7, 2024Cell Biology

Expanding the Huntingtons disease research toolbox; validated huntingtin subdomain constructs for biochemical and structural investigation of the huntingtin protein

M. G. Alteen, J. C. Deme, C. P. Alvarez, P. Loppnau, A. Hutchinson, A. Seitova, R. Chandrasekaran, E. Silva Ramos, C. Secker, M. Alqazzaz, E. E. Wanker, S. M. Lea, C. H. Arrowsmith, R. J. Harding

This paper develops validated HTT subdomain constructs for biochemical and structural studies of huntingtin protein interactions and function.

bioRxiv · Nov 21, 2022Biochemistry

Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants

S. A. Rodriguez-Aponte, N. C. Dalvie, T. Y. Wong, R. S. Johnston, C. A. Naranjo, S. Bajoria, O. S. Kumru, K. Kaur, B. P. Russ, K. S. Lee, H. A. Cyphert, M. Barbier, H. D. Rao, M. P. Rajurkar, R. R. Lothe, , J. C. Love

bioRxiv · Sep 14, 2022Bioengineering

Mapping Structural Drivers of Insulin Analogs Using Molecular Dynamics and Free Energy Calculations at Insulin Receptor

A. Ranganathan, M. M. M. Sena, R. Chandrasekaran, M. Chatterji, A. Khedkar, M. Gromiha

This study uses molecular dynamics and free energy calculations to analyze insulin-IR interactions and identify potency determinants in natural and synthetic insulin analogs.

bioRxiv · May 27, 2022 · PreprintBiophysics

Germinal center activity and B cell maturation promote protective antibody responses against Plasmodium pre-erythrocytic infection

G. R. Visweswaran, K. Vijayan, R. Chandrasekaran, O. Trakhimets, S. L. Whiteside, V. Vigdorovich, A. Yang, A. Raappana, A. Watson, W. Selman, M. Zuck, N. Dambrauskas, A. Kaushansky, D. N. Sather

This study compares vaccine-induced antibody responses in two mouse strains, finding that BALB/cJ mice develop stronger protective antibodies against Plasmodium due to enhanced B cell maturation and germinal center activity.

bioRxiv · Sep 10, 2021 · PreprintImmunology

Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium liver stage

K. Vijayan, R. Chandrasekaran, O. T. Trakhimets, S. L. Brown, N. Dambrauskas, M. Zuck, G. R. R. Visweswaran, A. Watson, A. Raappana, S. Carbonetti, L. Kelnhofer-Millevolte, E. K. K. Glennon, R. Postiglione, D. N. Sather, A. Kaushansky

This study shows non-neutralizing antibodies can reduce the effectiveness of neutralizing antibodies against Plasmodium CSP, impacting vaccine efficacy in malaria-exposed individuals.

bioRxiv · Sep 15, 2020Immunology