Author

A. Raappana

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. N. Sather· 4 shared A. Watson· 3 shared N. Dambrauskas· 3 shared V. Vigdorovich· 3 shared A. Kaushansky· 2 shared K. Vijayan· 2 shared M. Zuck· 2 shared O. Trakhimets· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

D. N. Sather

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Author profile →

4 papers

Recent·Most cited

Co-immunization with pre-erythrocytic antigens alongside circumsporozoite protein can enhance sterile protection against Plasmodium sporozoite infection.

V. Vigdorovich, H. Patel, A. Watson, A. Raappana, L. Reynolds, W. Selman, S. Beeman, P. T. Edlefsen, S. H. I. Kappe, D. N. Sather

This paper shows that combining multiple pre-erythrocytic antigens with CSP enhances sterile protection against Plasmodium sporozoite infection in a mouse model.

bioRxiv · Jun 17, 2022 · PreprintImmunology

Anti-TRAP/SSP2 monoclonal antibodies can inhibit sporozoite infection and enhance protection of anti-CSP monoclonal antibodies

B. K. Wilder, V. Vigdorovich, S. Carbonetti, N. Minkah, N. Hertoghs, A. Raappana, H. Cardamone, B. G. Oliver, O. Trakhimets, S. Kumar, N. Dambrauskas, S. A. Arredondo, N. Camargo, S. H. I. Kappe, D. N. Sather

This study shows that anti-TRAP/SSP2 monoclonal antibodies inhibit sporozoite infection and enhance protection from CSP-based antibodies, suggesting a multivalent vaccine strategy could improve malaria vaccines.

bioRxiv · Oct 15, 2021 · PreprintMicrobiology

Germinal center activity and B cell maturation promote protective antibody responses against Plasmodium pre-erythrocytic infection

G. R. Visweswaran, K. Vijayan, R. Chandrasekaran, O. Trakhimets, S. L. Whiteside, V. Vigdorovich, A. Yang, A. Raappana, A. Watson, W. Selman, M. Zuck, N. Dambrauskas, A. Kaushansky, D. N. Sather

This study compares vaccine-induced antibody responses in two mouse strains, finding that BALB/cJ mice develop stronger protective antibodies against Plasmodium due to enhanced B cell maturation and germinal center activity.

bioRxiv · Sep 10, 2021 · PreprintImmunology

Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium liver stage

K. Vijayan, R. Chandrasekaran, O. T. Trakhimets, S. L. Brown, N. Dambrauskas, M. Zuck, G. R. R. Visweswaran, A. Watson, A. Raappana, S. Carbonetti, L. Kelnhofer-Millevolte, E. K. K. Glennon, R. Postiglione, D. N. Sather, A. Kaushansky

This study shows non-neutralizing antibodies can reduce the effectiveness of neutralizing antibodies against Plasmodium CSP, impacting vaccine efficacy in malaria-exposed individuals.

bioRxiv · Sep 15, 2020Immunology