Author

N. Dambrauskas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Assay:protein structure· 1

Frequent Co-Authors

D. N. Sather· 6 shared V. Vigdorovich· 5 shared A. Raappana· 3 shared S. Carbonetti· 3 shared A. Kaushansky· 2 shared A. Watson· 2 shared B. K. Wilder· 2 shared K. Vijayan· 2 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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6 shared papersImmunology

D. N. Sather

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Anti-TRAP/SSP2 monoclonal antibodies can inhibit sporozoite infection and enhance protection of anti-CSP monoclonal antibodies

B. K. Wilder, V. Vigdorovich, S. Carbonetti, N. Minkah, N. Hertoghs, A. Raappana, H. Cardamone, B. G. Oliver, O. Trakhimets, S. Kumar, N. Dambrauskas, S. A. Arredondo, N. Camargo, S. H. I. Kappe, D. N. Sather

This study shows that anti-TRAP/SSP2 monoclonal antibodies inhibit sporozoite infection and enhance protection from CSP-based antibodies, suggesting a multivalent vaccine strategy could improve malaria vaccines.

bioRxiv · Oct 15, 2021 · PreprintMicrobiology

Germinal center activity and B cell maturation promote protective antibody responses against Plasmodium pre-erythrocytic infection

G. R. Visweswaran, K. Vijayan, R. Chandrasekaran, O. Trakhimets, S. L. Whiteside, V. Vigdorovich, A. Yang, A. Raappana, A. Watson, W. Selman, M. Zuck, N. Dambrauskas, A. Kaushansky, D. N. Sather

This study compares vaccine-induced antibody responses in two mouse strains, finding that BALB/cJ mice develop stronger protective antibodies against Plasmodium due to enhanced B cell maturation and germinal center activity.

bioRxiv · Sep 10, 2021 · PreprintImmunology

Vaccination with B.1.1.7, B.1.351 and P.1 variants protects mice from challenge with wild type SARS-CoV-2

F. Amanat, S. Strohmeier, P. Meade, N. Dambrauskas, B. Mühlemann, D. J. Smith, V. Vigdorovich, D. N. Sather, L. Coughlan, F. Krammer

This study evaluates cross-neutralizing antibody responses and protective efficacy of vaccines based on SARS-CoV-2 variants B.1.1.7, B.1.351, and P.1 in mice against wild type SARS-CoV-2 challenge.

bioRxiv · Aug 5, 2021 · PreprintImmunology

Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2

F. D. Mast, P. C. Fridy, N. E. Ketaren, J. Wang, E. Y. Jacobs, J. P. Olivier, T. Sanyal, K. R. Molloy, F. Schmidt, M. Rutkowska, Y. Weisblum, L. M. Rich, E. R. Vanderwall, N. Dambrauskas, V. Vigdorovich, , M. P. Rout

This paper presents a large repertoire of high-affinity nanobodies against SARS-CoV-2 Spike protein with potent neutralization properties and resistance to viral variants.

bioRxiv · Apr 8, 2021Biochemistry

Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium liver stage

K. Vijayan, R. Chandrasekaran, O. T. Trakhimets, S. L. Brown, N. Dambrauskas, M. Zuck, G. R. R. Visweswaran, A. Watson, A. Raappana, S. Carbonetti, L. Kelnhofer-Millevolte, E. K. K. Glennon, R. Postiglione, D. N. Sather, A. Kaushansky

This study shows non-neutralizing antibodies can reduce the effectiveness of neutralizing antibodies against Plasmodium CSP, impacting vaccine efficacy in malaria-exposed individuals.

bioRxiv · Sep 15, 2020Immunology

Platelet Derived Growth Factor Receptor β (PDGFRβ) is a Host Receptor for the human malaria parasite adhesin TRAP

R. W. J. Steel, V. Vigdorovich, N. Dambrauskas, B. K. Wilder, S. A. Arredondo, D. Goswami, S. Kumar, S. Carbonetti, K. E. Swearingen, T. Nguyen, W. Betz, N. Camargo, B. S. Fisher, J. Soden, H. Thomas, , S. H. I. Kappe

The paper identifies hPDGFRβ as a host receptor for the malaria parasite TRAP, showing its role in sporozoite motility and infection.

bioRxiv · May 12, 2020Microbiology